Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024755684> ?p ?o ?g. }
- W2024755684 endingPage "1855" @default.
- W2024755684 startingPage "1848" @default.
- W2024755684 abstract "Two polarized patterns (Th1 and Th2) of cytokines regulate inflammatory responses. Each cytokine pattern inhibits production of the opposing pattern. Lymphocytes from inflamed intestine due to Crohn's disease secrete a Th1 pattern of cytokines. Crohn's disease is most prevalent in highly industrialized countries with temperate climates. It occurs rarely in tropical third world countries with poor sanitation. We propose that exposure to an environmental agent predisposes individuals to Crohn's disease. Parasitic worms (helminths) are common in tropical climates and in populations subject to crowding and poor sanitation. Children are most subject to helminthic colonization. Many helminths live within or migrate through the human gut where they interact with the mucosal immune system. The host mounts a mucosal response that includes Th2 cytokine production limiting helminthic colonization. Helminths and their eggs probably are the most potent stimulators of mucosal Th2 responses. The Th2 response provoked by parasitic worms can modulate immune reactions to unrelated parasitic, bacterial, and viral infections. Many people in developed countries now live in increasingly hygienic environments, avoiding exposure to helminths. Perhaps failure to acquire these parasites and experience mucosal Th2 conditioning predisposes to Crohn's disease, which is an overly active Th1 inflammation." @default.
- W2024755684 created "2016-06-24" @default.
- W2024755684 creator A5054605206 @default.
- W2024755684 creator A5060649766 @default.
- W2024755684 creator A5075038210 @default.
- W2024755684 creator A5091173810 @default.
- W2024755684 date "2000-09-01" @default.
- W2024755684 modified "2023-10-14" @default.
- W2024755684 title "Does the failure to acquire helminthic parasites predispose to Crohn's disease?" @default.
- W2024755684 cites W1498658789 @default.
- W2024755684 cites W1507728691 @default.
- W2024755684 cites W1515615230 @default.
- W2024755684 cites W1515835638 @default.
- W2024755684 cites W1516330538 @default.
- W2024755684 cites W1517005233 @default.
- W2024755684 cites W1552622113 @default.
- W2024755684 cites W1561348059 @default.
- W2024755684 cites W1561588767 @default.
- W2024755684 cites W1565411191 @default.
- W2024755684 cites W1580094571 @default.
- W2024755684 cites W1611891187 @default.
- W2024755684 cites W1634158134 @default.
- W2024755684 cites W1647416578 @default.
- W2024755684 cites W1738194614 @default.
- W2024755684 cites W1771129259 @default.
- W2024755684 cites W1788537342 @default.
- W2024755684 cites W1845629018 @default.
- W2024755684 cites W1919714885 @default.
- W2024755684 cites W1924972785 @default.
- W2024755684 cites W1940408935 @default.
- W2024755684 cites W1942668068 @default.
- W2024755684 cites W1946093640 @default.
- W2024755684 cites W1959895049 @default.
- W2024755684 cites W1963907257 @default.
- W2024755684 cites W1966752763 @default.
- W2024755684 cites W1967076779 @default.
- W2024755684 cites W1968721249 @default.
- W2024755684 cites W1971119469 @default.
- W2024755684 cites W1978367456 @default.
- W2024755684 cites W1982166849 @default.
- W2024755684 cites W1989210966 @default.
- W2024755684 cites W1989857958 @default.
- W2024755684 cites W1998295547 @default.
- W2024755684 cites W2009495896 @default.
- W2024755684 cites W2012598225 @default.
- W2024755684 cites W2018075167 @default.
- W2024755684 cites W2021461294 @default.
- W2024755684 cites W2021706207 @default.
- W2024755684 cites W2034863253 @default.
- W2024755684 cites W2037061225 @default.
- W2024755684 cites W2037270543 @default.
- W2024755684 cites W2039748384 @default.
- W2024755684 cites W2039760034 @default.
- W2024755684 cites W2041244282 @default.
- W2024755684 cites W2046009712 @default.
- W2024755684 cites W2051229921 @default.
- W2024755684 cites W2058251150 @default.
- W2024755684 cites W2072933665 @default.
- W2024755684 cites W2077865652 @default.
- W2024755684 cites W2080898826 @default.
- W2024755684 cites W2088259154 @default.
- W2024755684 cites W2110395753 @default.
- W2024755684 cites W2113855055 @default.
- W2024755684 cites W2126742810 @default.
- W2024755684 cites W2134729501 @default.
- W2024755684 cites W21357486 @default.
- W2024755684 cites W2141679700 @default.
- W2024755684 cites W2142252231 @default.
- W2024755684 cites W2152776307 @default.
- W2024755684 cites W2153928526 @default.
- W2024755684 cites W2154354642 @default.
- W2024755684 cites W2155520575 @default.
- W2024755684 cites W2163737965 @default.
- W2024755684 cites W2168534336 @default.
- W2024755684 cites W2171819593 @default.
- W2024755684 cites W2175077154 @default.
- W2024755684 cites W2219659356 @default.
- W2024755684 cites W2258860422 @default.
- W2024755684 cites W2337230111 @default.
- W2024755684 cites W2337711722 @default.
- W2024755684 cites W2406842912 @default.
- W2024755684 cites W2409179355 @default.
- W2024755684 cites W2414277825 @default.
- W2024755684 cites W2916825506 @default.
- W2024755684 cites W4231581694 @default.
- W2024755684 cites W4237846258 @default.
- W2024755684 cites W4253782104 @default.
- W2024755684 cites W4301767415 @default.
- W2024755684 cites W962606866 @default.
- W2024755684 doi "https://doi.org/10.1096/fj.99-0885hyp" @default.
- W2024755684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10973934" @default.
- W2024755684 hasPublicationYear "2000" @default.
- W2024755684 type Work @default.
- W2024755684 sameAs 2024755684 @default.
- W2024755684 citedByCount "231" @default.
- W2024755684 countsByYear W20247556842012 @default.
- W2024755684 countsByYear W20247556842013 @default.
- W2024755684 countsByYear W20247556842014 @default.