Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024757365> ?p ?o ?g. }
- W2024757365 abstract "Acid suppression with a proton pump inhibitor is standard treatment for gastroesophageal reflux disease and erosive esophagitis in adults and increasingly is becoming first-line therapy for children aged 1-17 years. We evaluated endoscopic healing of erosive esophagitis with esomeprazole in young children with gastroesophageal reflux disease and described esophageal histology. Children aged 1-11 years with endoscopically or histologically confirmed gastroesophageal reflux disease were randomized to esomeprazole 5 or 10 mg daily (< 20 kg) or 10 or 20 mg daily (≥ 20 kg) for 8 weeks. Patients with erosive esophagitis underwent an endoscopy after 8 weeks to assess healing of erosions. Of 109 patients, 49% had erosive esophagitis and 51% had histologic evidence of reflux esophagitis without erosive esophagitis. Of the 45 patients who had erosive esophagitis and underwent follow-up endoscopy, 89% experienced erosion resolution. Dilation of intercellular space was reported in 24% of patients with histologic examination. Esomeprazole (0.2-1.0 mg/kg) effectively heals macroscopic and microscopic erosive esophagitis in this pediatric population with gastroesophageal reflux disease. Dilation of intercellular space may be an important histologic marker of erosive esophagitis in children. D9614C00097; ClinicalTrials.gov identifier NCT00228527." @default.
- W2024757365 created "2016-06-24" @default.
- W2024757365 creator A5001312234 @default.
- W2024757365 creator A5019196800 @default.
- W2024757365 creator A5024629646 @default.
- W2024757365 creator A5050279217 @default.
- W2024757365 creator A5069327677 @default.
- W2024757365 date "2010-06-11" @default.
- W2024757365 modified "2023-10-18" @default.
- W2024757365 title "Esomeprazole for the treatment of erosive esophagitis in children: an international, multicenter, randomized, parallel-group, double-blind (for dose) study" @default.
- W2024757365 cites W1784508678 @default.
- W2024757365 cites W1966218802 @default.
- W2024757365 cites W1977738286 @default.
- W2024757365 cites W1984728891 @default.
- W2024757365 cites W1985180598 @default.
- W2024757365 cites W2002095689 @default.
- W2024757365 cites W2017890107 @default.
- W2024757365 cites W2022798804 @default.
- W2024757365 cites W2026025287 @default.
- W2024757365 cites W2027062681 @default.
- W2024757365 cites W2029267188 @default.
- W2024757365 cites W2032094111 @default.
- W2024757365 cites W2040076099 @default.
- W2024757365 cites W2042158053 @default.
- W2024757365 cites W2045156833 @default.
- W2024757365 cites W2051273236 @default.
- W2024757365 cites W2059899768 @default.
- W2024757365 cites W2062609116 @default.
- W2024757365 cites W2062791759 @default.
- W2024757365 cites W2067477553 @default.
- W2024757365 cites W2078111035 @default.
- W2024757365 cites W2083561127 @default.
- W2024757365 cites W2085950564 @default.
- W2024757365 cites W2087678189 @default.
- W2024757365 cites W2097319019 @default.
- W2024757365 cites W2099961904 @default.
- W2024757365 cites W2105606912 @default.
- W2024757365 cites W2129769279 @default.
- W2024757365 cites W2141185001 @default.
- W2024757365 cites W2174068494 @default.
- W2024757365 cites W2323763104 @default.
- W2024757365 cites W2325404226 @default.
- W2024757365 cites W2411592032 @default.
- W2024757365 cites W4238774668 @default.
- W2024757365 cites W4249481007 @default.
- W2024757365 cites W79506128 @default.
- W2024757365 doi "https://doi.org/10.1186/1471-2431-10-41" @default.
- W2024757365 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2904294" @default.
- W2024757365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20540767" @default.
- W2024757365 hasPublicationYear "2010" @default.
- W2024757365 type Work @default.
- W2024757365 sameAs 2024757365 @default.
- W2024757365 citedByCount "26" @default.
- W2024757365 countsByYear W20247573652012 @default.
- W2024757365 countsByYear W20247573652013 @default.
- W2024757365 countsByYear W20247573652014 @default.
- W2024757365 countsByYear W20247573652015 @default.
- W2024757365 countsByYear W20247573652017 @default.
- W2024757365 countsByYear W20247573652018 @default.
- W2024757365 countsByYear W20247573652019 @default.
- W2024757365 countsByYear W20247573652021 @default.
- W2024757365 countsByYear W20247573652022 @default.
- W2024757365 countsByYear W20247573652023 @default.
- W2024757365 crossrefType "journal-article" @default.
- W2024757365 hasAuthorship W2024757365A5001312234 @default.
- W2024757365 hasAuthorship W2024757365A5019196800 @default.
- W2024757365 hasAuthorship W2024757365A5024629646 @default.
- W2024757365 hasAuthorship W2024757365A5050279217 @default.
- W2024757365 hasAuthorship W2024757365A5069327677 @default.
- W2024757365 hasBestOaLocation W20247573651 @default.
- W2024757365 hasConcept C126322002 @default.
- W2024757365 hasConcept C2777014526 @default.
- W2024757365 hasConcept C2778204628 @default.
- W2024757365 hasConcept C2778451229 @default.
- W2024757365 hasConcept C2779134260 @default.
- W2024757365 hasConcept C2779920096 @default.
- W2024757365 hasConcept C2781025758 @default.
- W2024757365 hasConcept C2908647359 @default.
- W2024757365 hasConcept C2909576783 @default.
- W2024757365 hasConcept C43270747 @default.
- W2024757365 hasConcept C71924100 @default.
- W2024757365 hasConcept C90924648 @default.
- W2024757365 hasConcept C99454951 @default.
- W2024757365 hasConceptScore W2024757365C126322002 @default.
- W2024757365 hasConceptScore W2024757365C2777014526 @default.
- W2024757365 hasConceptScore W2024757365C2778204628 @default.
- W2024757365 hasConceptScore W2024757365C2778451229 @default.
- W2024757365 hasConceptScore W2024757365C2779134260 @default.
- W2024757365 hasConceptScore W2024757365C2779920096 @default.
- W2024757365 hasConceptScore W2024757365C2781025758 @default.
- W2024757365 hasConceptScore W2024757365C2908647359 @default.
- W2024757365 hasConceptScore W2024757365C2909576783 @default.
- W2024757365 hasConceptScore W2024757365C43270747 @default.
- W2024757365 hasConceptScore W2024757365C71924100 @default.
- W2024757365 hasConceptScore W2024757365C90924648 @default.
- W2024757365 hasConceptScore W2024757365C99454951 @default.
- W2024757365 hasIssue "1" @default.
- W2024757365 hasLocation W20247573651 @default.
- W2024757365 hasLocation W20247573652 @default.
- W2024757365 hasLocation W20247573653 @default.