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- W2024758086 abstract "A dose-dependent decrease in infectivity was observed on introduction of eosinophils into suspensions of respiratory syncytial virus group B (RSV-B). This antiviral effect was reversed by ribo-nuclease inhibitor, suggesting a role for the eosinophil secretory ribonucleases. Recombinant eosino-phil- derived neurotoxin (rhEDN), the major eosinophil ribonuclease, promoted a dose-dependent decrease in RSV-B infectivity, with a 40-fold reduction observed in response to 50 nM rhEDN. Ribonucleolytically inactivated rhEDN (rhEDNdK38) had no antiviral activity. Semiquantitative reverse transcriptase-polymerase chain reaction demonstrated loss of viral genomic RNA in response to rhEDN, suggesting that this protein promotes the direct ribonucleolytic destruction of extracellular virions. Ribonuclease A had no antiviral activity even at ∼ 1000-fold higher concentrations, suggesting that rhEDN has unique features other than ribonuclease activity that are crucial to its effectiveness. These results suggest that rhEDN may have potential as a therapeutic agent for prevention or treatment of disease caused by RSV." @default.
- W2024758086 created "2016-06-24" @default.
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- W2024758086 date "1998-06-01" @default.
- W2024758086 modified "2023-09-30" @default.
- W2024758086 title "Recombinant Human Eosinophil‐Derived Neurotoxin/RNase 2 Functions as an Effective Antiviral Agent against Respiratory Syncytial Virus" @default.
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- W2024758086 doi "https://doi.org/10.1086/515322" @default.
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