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• W2024761791 abstract "Peroxisome proliferator-activated receptor-gamma (PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>) exerts multiple functions in determination of cell fate, tissue metabolism, and host immunity. Two synthetic PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>ligands (rosiglitazone and pioglitazone) were approved for the therapy of type-2 diabetes mellitus and are expected to serve as novel cures for inflammatory diseases and cancer. However, PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>and its ligands exhibit a janus-face behaviour as tumor modulators in various systems, resulting in either tumor suppression or tumor promotion. This may be in part due to signaling crosstalk to the mitogen-activated protein kinase (MAPK) cascades. The genomic activity of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2). PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>ligands themselves activate the ERK cascade through nongenomic and often PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>-independent signaling. In the current review, we discuss the molecular mechanisms and physiological implications of the crosstalk of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>with MEK-ERK signaling and its potential as a novel drug target for cancer therapy in patients." @default.
• W2024761791 created "2016-06-24" @default.
• W2024761791 creator A5060020593 @default.
• W2024761791 creator A5079331236 @default.
• W2024761791 date "2008-01-01" @default.
• W2024761791 modified "2023-10-14" @default.
• W2024761791 title "PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>and MEK Interactions in Cancer" @default.
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