FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024762950> ?p ?o ?g. }

• W2024762950 endingPage "258" @default.
• W2024762950 startingPage "258" @default.
• W2024762950 abstract "The continuous administration of GnRH leads to the desensitization and down-regulation of GnRH receptors on pituitary gonadotropes (Parker and Schimmer 2001 in Goodman & Gilman's The Pharmacological Basis of Therapeutics, New York: McGraw-Hill, 1541–1562). In this study, we combined the use of a GnRH analogue with calcium/naloxone association (Sciorsci et al. 2000 Immunopharmacol. Immunotoxicol. 22, 575−626) to obtain a desensitizing effect on LH receptors in an attempt to regulate spermatogenesis in dogs. Eight post-pubertal mixed breed dogs were divided into two groups: (A) four subjects were pharmacologically treated with a 30 day administration of buserelin acetate (Suprefact Aventis Pharma, Italy) 0.3 mg/each s.c. TID, associated with 0.1-mL/kg/bw i.m. injection SID of calcium gluconate 20% (New ICC, Upjohn, Italy) in which 0.4 mg/mL of naloxone hydrochloride (Diosynth, The Netherlands) was dissolved; (B) four subjects received placebo (NaCl 0.9% s.c. TID for 30 days). At the end of the treatment, hemiorchidectomy was performed and 4 months later the second testis was removed. Clinical examination of the genital tract was done by ultrasound monitoring. Before and after pharmacological treatment and until total orchidectomy, semen was collected and evaluated for macroscopic and microscopic parameters. Plasma testosterone concentration was measured twice a week by RIA. Testicular specimens were fixed in formalin solution, embedded in paraffin wax and stained with hematoxylin–eosin. The presence of germ cells and the testicular tubule diameters were analyzed using a computer assisted image analyzer (MONO system, Italy). Data were analyzed by the ANOVA test. In the treated group, all dogs showed a reduction in testicular and prostatic diameters compared to the control group. Transient elevations in testosterone concentrations were observed in response to the early injections and reached baseline levels after 8–10 days. The testosterone decline resulted in lower ejaculate volume and, at the end of treatment, azoospermia was observed. At the end of treatment, testosterone values had progressively regained normal values over 2 months and, when measured immediately before total orchidectomy, sperm concentration and motility had returned to normal. At the histological observation, seminiferous tubules showed the block of spermatogenesis at the level of spermatocytes with a statistically significant cell reduction in spermatides and spermatozoa (P < 0.001) whereas the seminiferous tubular morphometry was normal. Total orchidectomy demonstrated that a normal histological testicular structure had been restored. In the control group, no modifications were observed. As observed in a previous study (Aiudi et al. 2005 Reprod. Fert. Dev. 17(2), 280–281), GnRH induced suppression of the reproductive function in male dogs. In this study, we demonstrated that GnRH analogue associated with calcium and naloxone induces the same effect in a shorter time and that this effect is reversible. These devices designed for the shutdown of gonadal steroidogenesis and spermatogenesis would be useful for treating sex hormone-dependent syndromes such as malignant and benign prostatic tumors." @default.
• W2024762950 created "2016-06-24" @default.
• W2024762950 creator A5018690413 @default.
• W2024762950 creator A5049617783 @default.
• W2024762950 creator A5051052058 @default.
• W2024762950 creator A5064709393 @default.
• W2024762950 creator A5075875074 @default.
• W2024762950 creator A5089402350 @default.
• W2024762950 date "2006-01-01" @default.
• W2024762950 modified "2023-09-26" @default.
• W2024762950 title "301 NEW APPROACHES TO CONTRACEPTION IN DOGS USING GnRH ANALOGUES, CALCIUM, AND NALOXONE" @default.
• W2024762950 doi "https://doi.org/10.1071/rdv18n2ab301" @default.
• W2024762950 hasPublicationYear "2006" @default.
• W2024762950 type Work @default.
• W2024762950 sameAs 2024762950 @default.
• W2024762950 citedByCount "0" @default.
• W2024762950 crossrefType "journal-article" @default.
• W2024762950 hasAuthorship W2024762950A5018690413 @default.
• W2024762950 hasAuthorship W2024762950A5049617783 @default.
• W2024762950 hasAuthorship W2024762950A5051052058 @default.
• W2024762950 hasAuthorship W2024762950A5064709393 @default.
• W2024762950 hasAuthorship W2024762950A5075875074 @default.
• W2024762950 hasAuthorship W2024762950A5089402350 @default.
• W2024762950 hasConcept C126322002 @default.
• W2024762950 hasConcept C134018914 @default.
• W2024762950 hasConcept C170493617 @default.
• W2024762950 hasConcept C185592680 @default.
• W2024762950 hasConcept C2777230143 @default.
• W2024762950 hasConcept C2778938600 @default.
• W2024762950 hasConcept C2779279991 @default.
• W2024762950 hasConcept C71924100 @default.
• W2024762950 hasConceptScore W2024762950C126322002 @default.
• W2024762950 hasConceptScore W2024762950C134018914 @default.
• W2024762950 hasConceptScore W2024762950C170493617 @default.
• W2024762950 hasConceptScore W2024762950C185592680 @default.
• W2024762950 hasConceptScore W2024762950C2777230143 @default.
• W2024762950 hasConceptScore W2024762950C2778938600 @default.
• W2024762950 hasConceptScore W2024762950C2779279991 @default.
• W2024762950 hasConceptScore W2024762950C71924100 @default.
• W2024762950 hasIssue "2" @default.
• W2024762950 hasLocation W20247629501 @default.
• W2024762950 hasOpenAccess W2024762950 @default.
• W2024762950 hasPrimaryLocation W20247629501 @default.
• W2024762950 hasRelatedWork W1990734846 @default.
• W2024762950 hasRelatedWork W1998113603 @default.
• W2024762950 hasRelatedWork W2014200423 @default.
• W2024762950 hasRelatedWork W2027237635 @default.
• W2024762950 hasRelatedWork W2035476273 @default.
• W2024762950 hasRelatedWork W2103405978 @default.
• W2024762950 hasRelatedWork W2107351787 @default.
• W2024762950 hasRelatedWork W2112835642 @default.
• W2024762950 hasRelatedWork W2167615245 @default.
• W2024762950 hasRelatedWork W2748952813 @default.
• W2024762950 hasVolume "18" @default.
• W2024762950 isParatext "false" @default.
• W2024762950 isRetracted "false" @default.
• W2024762950 magId "2024762950" @default.
• W2024762950 workType "article" @default.