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• W2024767022 abstract "Objectives . Genome wide association studies identified TNFSF member TNF-like protein 1A (TL1A, TNFSF15) as a potential modulator of ankylosing spondylitis (AS). TL1A is the only confirmed TNFSF ligand of death receptor 3 (DR3, TNFRSF25); however, its role in disease pathology is not characterised. We evaluated DR3’s role in controlling osteoblast- (OB-) dependent bone formation in vitro and in vivo . Methods . Osteoprogenitor cells and OB were cultured from male DR3-deficient (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mtext>DR</mml:mtext><mml:msup><mml:mrow><mml:mn mathvariant=normal>3</mml:mn></mml:mrow><mml:mrow><mml:mtext>ko</mml:mtext></mml:mrow></mml:msup></mml:math>) and wild-type (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mtext>DR</mml:mtext><mml:msup><mml:mrow><mml:mn mathvariant=normal>3</mml:mn></mml:mrow><mml:mrow><mml:mtext>wt</mml:mtext></mml:mrow></mml:msup></mml:math>) DBA/1 mice. DR3 and RANKL expression were tested by flow cytometry. Alkaline phosphatase and mineralization were quantified. Osteopontin, osteoprotegerin, and pro MMP-9 were measured by ELISA. A fluorescent probe (BoneTag) was used to measure in vivo mineralization in 10-month-old mice. Results . DR3 was expressed on osteoprogenitors and OB from<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mtext>DR</mml:mtext><mml:msup><mml:mrow><mml:mn mathvariant=normal>3</mml:mn></mml:mrow><mml:mrow><mml:mtext>wt</mml:mtext></mml:mrow></mml:msup></mml:math>mice. Alkaline phosphatase, osteopontin, and mineral apposition were significantly elevated in<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mtext>DR</mml:mtext><mml:msup><mml:mrow><mml:mn mathvariant=normal>3</mml:mn></mml:mrow><mml:mrow><mml:mtext>wt</mml:mtext></mml:mrow></mml:msup></mml:math>cultures. Levels of RANKL were comparable whilst osteoprotegerin was significantly increased in<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mtext>DR</mml:mtext><mml:msup><mml:mrow><mml:mn mathvariant=normal>3</mml:mn></mml:mrow><mml:mrow><mml:mtext>wt</mml:mtext></mml:mrow></mml:msup></mml:math>cultures. In vivo incorporation of BoneTag was significantly lower in the thoracic vertebrae of 10-month-old<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mtext>DR</mml:mtext><mml:msup><mml:mrow><mml:mn mathvariant=normal>3</mml:mn></mml:mrow><mml:mrow><mml:mtext>ko</mml:mtext></mml:mrow></mml:msup></mml:math>mice. Conclusions . These data identify new roles for DR3 in regulating OB-dependent bone mineral apposition. They potentially begin to explain the atypical pattern of new bone formation observed in the axial skeleton of grouped, aging DBA/1 mice." @default.
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• W2024767022 date "2015-01-01" @default.
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• W2024767022 title "Death Receptor 3 (TNFRSF25) Increases Mineral Apposition by Osteoblasts and Region Specific New Bone Formation in the Axial Skeleton of Male DBA/1 Mice" @default.
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• W2024767022 doi "https://doi.org/10.1155/2015/901679" @default.
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