FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024768242> ?p ?o ?g. }

• W2024768242 endingPage "1229" @default.
• W2024768242 startingPage "1229" @default.
• W2024768242 abstract "Grant Dorsey and co-workers (Dec 21/28, p 2031)1Dorsey G Njama D Kamya MR et al.Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.Lancet. 2002; 360: 2031-2038Summary Full Text Full Text PDF PubMed Scopus (122) Google Scholar recommend sulfadoxine/pyrimethamine with amo-diaquine for treatment of malaria in Uganda. This regimen was more successful than sulfadoxine/ pyrimethamine alone or in combination with artesunate.The chequered history of amodiaquine warrants some comment. This antimalarial was briefly recommended for prophylaxis in travellers during the 1980s, but was subsequently abandoned after reports that it can induce immune-mediated granulocytopenia in one of 2000 patients.2Hatton CS Peto TE Bunch C et al.Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.Lancet. 1986; 1: 411-414Summary PubMed Scopus (197) Google Scholar By matter of comparison, this is roughly 20 times the incidence of aplastic anaemia caused by chloramphenicol.I was, therefore, surprised to find that Dorsey and colleagues make no mention of leucocyte counts. Their study design seems to preclude discovery of granulocytopenia, if, indeed, it did occur. Can one be sure that the one death reported was caused by malaria, and not by sepsis secondary to granulocytopenia?There are, of course, other treatment options for malaria, such as mefloquine. How do you weigh the high cost of mefloquine against the risk of severe granulocytopenia associated with amodiaquine? Grant Dorsey and co-workers (Dec 21/28, p 2031)1Dorsey G Njama D Kamya MR et al.Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.Lancet. 2002; 360: 2031-2038Summary Full Text Full Text PDF PubMed Scopus (122) Google Scholar recommend sulfadoxine/pyrimethamine with amo-diaquine for treatment of malaria in Uganda. This regimen was more successful than sulfadoxine/ pyrimethamine alone or in combination with artesunate. The chequered history of amodiaquine warrants some comment. This antimalarial was briefly recommended for prophylaxis in travellers during the 1980s, but was subsequently abandoned after reports that it can induce immune-mediated granulocytopenia in one of 2000 patients.2Hatton CS Peto TE Bunch C et al.Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.Lancet. 1986; 1: 411-414Summary PubMed Scopus (197) Google Scholar By matter of comparison, this is roughly 20 times the incidence of aplastic anaemia caused by chloramphenicol. I was, therefore, surprised to find that Dorsey and colleagues make no mention of leucocyte counts. Their study design seems to preclude discovery of granulocytopenia, if, indeed, it did occur. Can one be sure that the one death reported was caused by malaria, and not by sepsis secondary to granulocytopenia? There are, of course, other treatment options for malaria, such as mefloquine. How do you weigh the high cost of mefloquine against the risk of severe granulocytopenia associated with amodiaquine? Questions about the antimalarial amodiaquineAuthors' reply Full-Text PDF" @default.
• W2024768242 created "2016-06-24" @default.
• W2024768242 creator A5060213700 @default.
• W2024768242 date "2003-04-01" @default.
• W2024768242 modified "2023-10-14" @default.
• W2024768242 title "Questions about the antimalarial amodiaquine" @default.
• W2024768242 cites W2033261946 @default.
• W2024768242 cites W2170936619 @default.
• W2024768242 cites W3144690869 @default.
• W2024768242 doi "https://doi.org/10.1016/s0140-6736(03)12943-1" @default.
• W2024768242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12686075" @default.
• W2024768242 hasPublicationYear "2003" @default.
• W2024768242 type Work @default.
• W2024768242 sameAs 2024768242 @default.
• W2024768242 citedByCount "3" @default.
• W2024768242 countsByYear W20247682422015 @default.
• W2024768242 crossrefType "journal-article" @default.
• W2024768242 hasAuthorship W2024768242A5060213700 @default.
• W2024768242 hasConcept C126322002 @default.
• W2024768242 hasConcept C187212893 @default.
• W2024768242 hasConcept C203014093 @default.
• W2024768242 hasConcept C2776992834 @default.
• W2024768242 hasConcept C2777035104 @default.
• W2024768242 hasConcept C2777199930 @default.
• W2024768242 hasConcept C2777425658 @default.
• W2024768242 hasConcept C2778048844 @default.
• W2024768242 hasConcept C2778059366 @default.
• W2024768242 hasConcept C2778301690 @default.
• W2024768242 hasConcept C2778371730 @default.
• W2024768242 hasConcept C2780441369 @default.
• W2024768242 hasConcept C2781413609 @default.
• W2024768242 hasConcept C71924100 @default.
• W2024768242 hasConcept C98274493 @default.
• W2024768242 hasConceptScore W2024768242C126322002 @default.
• W2024768242 hasConceptScore W2024768242C187212893 @default.
• W2024768242 hasConceptScore W2024768242C203014093 @default.
• W2024768242 hasConceptScore W2024768242C2776992834 @default.
• W2024768242 hasConceptScore W2024768242C2777035104 @default.
• W2024768242 hasConceptScore W2024768242C2777199930 @default.
• W2024768242 hasConceptScore W2024768242C2777425658 @default.
• W2024768242 hasConceptScore W2024768242C2778048844 @default.
• W2024768242 hasConceptScore W2024768242C2778059366 @default.
• W2024768242 hasConceptScore W2024768242C2778301690 @default.
• W2024768242 hasConceptScore W2024768242C2778371730 @default.
• W2024768242 hasConceptScore W2024768242C2780441369 @default.
• W2024768242 hasConceptScore W2024768242C2781413609 @default.
• W2024768242 hasConceptScore W2024768242C71924100 @default.
• W2024768242 hasConceptScore W2024768242C98274493 @default.
• W2024768242 hasIssue "9364" @default.
• W2024768242 hasLocation W20247682421 @default.
• W2024768242 hasLocation W20247682422 @default.
• W2024768242 hasOpenAccess W2024768242 @default.
• W2024768242 hasPrimaryLocation W20247682421 @default.
• W2024768242 hasRelatedWork W1599232107 @default.
• W2024768242 hasRelatedWork W1978608749 @default.
• W2024768242 hasRelatedWork W2067969604 @default.
• W2024768242 hasRelatedWork W2101046223 @default.
• W2024768242 hasRelatedWork W2148974692 @default.
• W2024768242 hasRelatedWork W2168428623 @default.
• W2024768242 hasRelatedWork W2417810012 @default.
• W2024768242 hasRelatedWork W3122486255 @default.
• W2024768242 hasRelatedWork W4281979899 @default.
• W2024768242 hasRelatedWork W654520814 @default.
• W2024768242 hasVolume "361" @default.
• W2024768242 isParatext "false" @default.
• W2024768242 isRetracted "false" @default.
• W2024768242 magId "2024768242" @default.
• W2024768242 workType "article" @default.