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- W2024770192 abstract "There is enough evidence that erythropoietin (EPO) may be involved in cardiovascular function. Therefore we have investigated the possible effects of EPO on left ventricular developed pressure, +dP/dtmax, heart rate, tissue cAMP, and nitrite levels. Isolated rat hearts were perfused under constant flow (10 ml/min) conditions with modified Krebs-Henseleit solution and recombinant human erythropoietin at doses of 100, 200, 500, and 1,000 IU/kg was administered as bolus injections. EPO at 100 IU/kg decreased, but higher doses (500 and 1,000 IU/kg) raised the developed pressure and +dP/dtmax. However, it did not affect heart rate or coronary perfusion pressure when all the respective doses were applied. EPO at 100 IU/kg increased nitrite, and at 1,000 IU/kg it raised cAMP. Our results suggest that EPO may produce dose-dependently negative and positive inotropic effects on myocardial contractility in isolated rat hearts. NO and cAMP may be involved in negative and positive inotropic effects of EPO, respectively." @default.
- W2024770192 created "2016-06-24" @default.
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- W2024770192 date "2006-01-01" @default.
- W2024770192 modified "2023-10-18" @default.
- W2024770192 title "Erythropoietin Changes Contractility, cAMP, and Nitrite Levels of Isolated Rat Hearts" @default.
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- W2024770192 doi "https://doi.org/10.2170/physiolsci.rp004806" @default.
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