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- W2024774534 abstract "The transmembrane protein Brother of Cdo (Boc) has been implicated in Shh-mediated commissural axon guidance, and can both positively and negatively regulate Hedgehog (Hh) target gene transcription, however, little is known about in vivo requirements for Boc during vertebrate embryogenesis. The zebrafish umleitung (umlty54) mutant was identified by defects in retinotectal axon projections. Here, we show that the uml locus encodes Boc and that Boc function is cell-autonomously required for Hh-mediated neural patterning. Our phenotypic analysis suggests that Boc is required as a positive regulator of Hh signaling in the spinal cord, hypothalamus, pituitary, somites and upper jaw, but that Boc might negatively regulate Hh signals in the lower jaw. This study reveals a role for Boc in ventral CNS cells that receive high levels of Hh and uncovers previously unknown roles for Boc in vertebrate embryogenesis." @default.
- W2024774534 created "2016-06-24" @default.
- W2024774534 creator A5000228728 @default.
- W2024774534 creator A5020199481 @default.
- W2024774534 creator A5046373660 @default.
- W2024774534 creator A5049482661 @default.
- W2024774534 creator A5069574773 @default.
- W2024774534 date "2011-01-01" @default.
- W2024774534 modified "2023-10-03" @default.
- W2024774534 title "<i>brother of cdo</i> (<i>umleitung</i>) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish" @default.
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- W2024774534 doi "https://doi.org/10.1242/dev.057950" @default.
- W2024774534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2998166" @default.
- W2024774534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21115611" @default.
- W2024774534 hasPublicationYear "2011" @default.
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