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- W2024774586 abstract "IgM exists as both a monomer on the surface of B cells and a pentamer secreted by plasma cells. Both pre-immune “natural” and antigen-induced “immune” IgM antibodies are important for protective immunity and for immune regulation of autoimmune processes by recognizing pathogens and self-antigens. Effector proteins interacting with the Fc portion of IgM, such as complement and complement receptors, have thus far been proposed but fail to fully account for the IgM-mediated protection and regulation. A major reason for this deficit in our understanding of IgM function seems to be lack of data on a long elusive Fc receptor for IgM (FcμR). We have recently identified a bona fide FcμR in both humans and mice. In this article we briefly review what we have learned so far about FcμR." @default.
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- W2024774586 date "2014-05-03" @default.
- W2024774586 modified "2023-10-01" @default.
- W2024774586 title "The Long Elusive IgM Fc Receptor, FcμR" @default.
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- W2024774586 doi "https://doi.org/10.1007/s10875-014-0022-7" @default.
- W2024774586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4160156" @default.
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- W2024774586 hasPublicationYear "2014" @default.
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