FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024776736> ?p ?o ?g. }

• W2024776736 endingPage "1038" @default.
• W2024776736 startingPage "1031" @default.
• W2024776736 abstract "Background Studies in European Americans (EAs) have shown that the hypothalamic–pituitary–adrenal (HPA)-axis activation by the opioid blockade is moderated by the single nucleotide polymorphism (SNP) A118G (Asn40Asp) at the μ-opioid receptor locus (OPRM1). We examined the effect of this, and of five intronic OPRM1 SNPs, on adrenocorticotropic hormone and cortisol concentrations, following the placebo-controlled administration of naloxone to healthy individuals who were of EA or Asian ancestry. Methods We used a balanced, within-participant design with two test sessions to examine the hormonal responses to intravenous naloxone (an opioid antagonist) (125 μg/kg) or placebo in 29 healthy participants (62% men, 59% of Asian ancestry). DNA isolated from whole blood was PCR amplified and genotyped using a fluorogenic 5 nuclease assay (TaqMan) method. Results Consistent with earlier reports, participants with one or two Asp40 alleles (n=16) had a significantly greater cortisol response to naloxone than Asn40 homozygotes, but the effect was limited to EAs. Asians with the Asp40 allele did not show a greater increase in cortisol response compared with Asn40 homozygotes. None of the intronic SNPs was associated with cortisol response either directly or via an interaction effect with Asn40Asp. Conclusions Effects of the Asn40Asp polymorphism at OPRM1 on HPA-axis activation seem to be population-specific. The association between the Asn40Asp and the HPA-axis response to naloxone cannot, therefore, be explained with reference only to the amino acid substitution encoded by that polymorphism. Further research to understand the basis for the observed association is warranted." @default.
• W2024776736 created "2016-06-24" @default.
• W2024776736 creator A5012145971 @default.
• W2024776736 creator A5015100835 @default.
• W2024776736 creator A5044047568 @default.
• W2024776736 creator A5045269183 @default.
• W2024776736 creator A5055429568 @default.
• W2024776736 creator A5075961872 @default.
• W2024776736 date "2007-12-01" @default.
• W2024776736 modified "2023-10-16" @default.
• W2024776736 title "Population-specific effects of the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1) on HPA-axis activation" @default.
• W2024776736 cites W1570074927 @default.
• W2024776736 cites W192884275 @default.
• W2024776736 cites W1971558659 @default.
• W2024776736 cites W1974666828 @default.
• W2024776736 cites W1976124176 @default.
• W2024776736 cites W1978715208 @default.
• W2024776736 cites W1980737710 @default.
• W2024776736 cites W1980896189 @default.
• W2024776736 cites W1983242089 @default.
• W2024776736 cites W1983420008 @default.
• W2024776736 cites W1989180746 @default.
• W2024776736 cites W1989309280 @default.
• W2024776736 cites W1991038498 @default.
• W2024776736 cites W1996783118 @default.
• W2024776736 cites W1998722031 @default.
• W2024776736 cites W2007655676 @default.
• W2024776736 cites W2012743573 @default.
• W2024776736 cites W2014534739 @default.
• W2024776736 cites W2026132680 @default.
• W2024776736 cites W2044153999 @default.
• W2024776736 cites W2056233911 @default.
• W2024776736 cites W2056738734 @default.
• W2024776736 cites W2063017492 @default.
• W2024776736 cites W2069018102 @default.
• W2024776736 cites W2069769149 @default.
• W2024776736 cites W2071692287 @default.
• W2024776736 cites W2076942602 @default.
• W2024776736 cites W2080253238 @default.
• W2024776736 cites W2104786490 @default.
• W2024776736 cites W2121114239 @default.
• W2024776736 cites W2156925439 @default.
• W2024776736 cites W2162530578 @default.
• W2024776736 cites W2171187460 @default.
• W2024776736 cites W2316870002 @default.
• W2024776736 cites W3120415379 @default.
• W2024776736 doi "https://doi.org/10.1097/fpc.0b013e3282f0b99c" @default.
• W2024776736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18004207" @default.
• W2024776736 hasPublicationYear "2007" @default.
• W2024776736 type Work @default.
• W2024776736 sameAs 2024776736 @default.
• W2024776736 citedByCount "59" @default.
• W2024776736 countsByYear W20247767362012 @default.
• W2024776736 countsByYear W20247767362013 @default.
• W2024776736 countsByYear W20247767362014 @default.
• W2024776736 countsByYear W20247767362015 @default.
• W2024776736 countsByYear W20247767362016 @default.
• W2024776736 countsByYear W20247767362017 @default.
• W2024776736 countsByYear W20247767362018 @default.
• W2024776736 countsByYear W20247767362019 @default.
• W2024776736 countsByYear W20247767362020 @default.
• W2024776736 countsByYear W20247767362021 @default.
• W2024776736 countsByYear W20247767362022 @default.
• W2024776736 crossrefType "journal-article" @default.
• W2024776736 hasAuthorship W2024776736A5012145971 @default.
• W2024776736 hasAuthorship W2024776736A5015100835 @default.
• W2024776736 hasAuthorship W2024776736A5044047568 @default.
• W2024776736 hasAuthorship W2024776736A5045269183 @default.
• W2024776736 hasAuthorship W2024776736A5055429568 @default.
• W2024776736 hasAuthorship W2024776736A5075961872 @default.
• W2024776736 hasConcept C104317684 @default.
• W2024776736 hasConcept C126322002 @default.
• W2024776736 hasConcept C134018914 @default.
• W2024776736 hasConcept C135763542 @default.
• W2024776736 hasConcept C142724271 @default.
• W2024776736 hasConcept C149737253 @default.
• W2024776736 hasConcept C153209595 @default.
• W2024776736 hasConcept C170493617 @default.
• W2024776736 hasConcept C180754005 @default.
• W2024776736 hasConcept C204787440 @default.
• W2024776736 hasConcept C27081682 @default.
• W2024776736 hasConcept C2778709874 @default.
• W2024776736 hasConcept C2779886867 @default.
• W2024776736 hasConcept C2780546910 @default.
• W2024776736 hasConcept C2781063702 @default.
• W2024776736 hasConcept C2908647359 @default.
• W2024776736 hasConcept C54355233 @default.
• W2024776736 hasConcept C71315377 @default.
• W2024776736 hasConcept C71924100 @default.
• W2024776736 hasConcept C86803240 @default.
• W2024776736 hasConcept C99454951 @default.
• W2024776736 hasConceptScore W2024776736C104317684 @default.
• W2024776736 hasConceptScore W2024776736C126322002 @default.
• W2024776736 hasConceptScore W2024776736C134018914 @default.
• W2024776736 hasConceptScore W2024776736C135763542 @default.
• W2024776736 hasConceptScore W2024776736C142724271 @default.
• W2024776736 hasConceptScore W2024776736C149737253 @default.
• W2024776736 hasConceptScore W2024776736C153209595 @default.

• next