FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024776857> ?p ?o ?g. }

• W2024776857 endingPage "4913" @default.
• W2024776857 startingPage "4905" @default.
• W2024776857 abstract "An effective vaccine for severe acute respiratory syndrome (SARS) will probably require the generation and maintenance of both humoral and cellular immune responses. It has been reported that after natural infection in humans and immunization in animals with SARS-CoV vaccine, antibody is produced and persistent for a long period of time. In the present study, mice were immunized i.m. with SARS-CoV S DNA vaccine, and three different methods (ELISA, ELISPOT and FACS) were used to evaluate the immune responses when the cells were stimulated in vitro with a pool of peptides overlapping entire SARS spike protein. The results show that prime-immunization with SARS-CoV S DNA vaccine can induce both CD4+ and CD8+ T cell responses. Boosting with the same vaccine enhances CD4+ and CD8+ T cell responses in both lymphoid and nonlymphoid organs and were persistent over two months. The SARS-CoV S-specific CD4+ and CD8+ T cells were CD62L−, a marker for memory cells, and −30 to 50% of the cells expressed IL-7Rα (CD127), a marker for the capacity of effector cells to develop into memory cells. In addition, immunization with the DNA vaccine elicited high levels of antibody production. Taken together, these data demonstrate that immunization with SARS-CoV S DNA vaccine can generate antigen-specific humoral and cellular immune responses that may contribute to long-term protection." @default.
• W2024776857 created "2016-06-24" @default.
• W2024776857 creator A5012837632 @default.
• W2024776857 creator A5017371410 @default.
• W2024776857 creator A5079323187 @default.
• W2024776857 date "2006-06-01" @default.
• W2024776857 modified "2023-09-28" @default.
• W2024776857 title "Immunization with SARS-CoV S DNA vaccine generates memory CD4+ and CD8+ T cell immune responses" @default.
• W2024776857 cites W1493822493 @default.
• W2024776857 cites W1512247569 @default.
• W2024776857 cites W1607296675 @default.
• W2024776857 cites W1972591948 @default.
• W2024776857 cites W1974842026 @default.
• W2024776857 cites W1981471067 @default.
• W2024776857 cites W1998383538 @default.
• W2024776857 cites W2003015789 @default.
• W2024776857 cites W2010424791 @default.
• W2024776857 cites W2016685455 @default.
• W2024776857 cites W2025170735 @default.
• W2024776857 cites W2025484368 @default.
• W2024776857 cites W2029128444 @default.
• W2024776857 cites W2034160168 @default.
• W2024776857 cites W2040360774 @default.
• W2024776857 cites W2061675358 @default.
• W2024776857 cites W2062614452 @default.
• W2024776857 cites W2102303272 @default.
• W2024776857 cites W2103776139 @default.
• W2024776857 cites W2111888415 @default.
• W2024776857 cites W2116586125 @default.
• W2024776857 cites W2125788479 @default.
• W2024776857 cites W2131643524 @default.
• W2024776857 cites W2131748930 @default.
• W2024776857 cites W2132260239 @default.
• W2024776857 cites W2141730450 @default.
• W2024776857 cites W2153987199 @default.
• W2024776857 cites W2167080692 @default.
• W2024776857 cites W2171157147 @default.
• W2024776857 doi "https://doi.org/10.1016/j.vaccine.2006.03.058" @default.
• W2024776857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7115633" @default.
• W2024776857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16621188" @default.
• W2024776857 hasPublicationYear "2006" @default.
• W2024776857 type Work @default.
• W2024776857 sameAs 2024776857 @default.
• W2024776857 citedByCount "32" @default.
• W2024776857 countsByYear W20247768572012 @default.
• W2024776857 countsByYear W20247768572014 @default.
• W2024776857 countsByYear W20247768572020 @default.
• W2024776857 countsByYear W20247768572021 @default.
• W2024776857 countsByYear W20247768572022 @default.
• W2024776857 crossrefType "journal-article" @default.
• W2024776857 hasAuthorship W2024776857A5012837632 @default.
• W2024776857 hasAuthorship W2024776857A5017371410 @default.
• W2024776857 hasAuthorship W2024776857A5079323187 @default.
• W2024776857 hasBestOaLocation W20247768571 @default.
• W2024776857 hasConcept C123982805 @default.
• W2024776857 hasConcept C147483822 @default.
• W2024776857 hasConcept C159047783 @default.
• W2024776857 hasConcept C159654299 @default.
• W2024776857 hasConcept C167508917 @default.
• W2024776857 hasConcept C167672396 @default.
• W2024776857 hasConcept C203014093 @default.
• W2024776857 hasConcept C2776090121 @default.
• W2024776857 hasConcept C2779053233 @default.
• W2024776857 hasConcept C2780801004 @default.
• W2024776857 hasConcept C79484868 @default.
• W2024776857 hasConcept C86803240 @default.
• W2024776857 hasConcept C8891405 @default.
• W2024776857 hasConceptScore W2024776857C123982805 @default.
• W2024776857 hasConceptScore W2024776857C147483822 @default.
• W2024776857 hasConceptScore W2024776857C159047783 @default.
• W2024776857 hasConceptScore W2024776857C159654299 @default.
• W2024776857 hasConceptScore W2024776857C167508917 @default.
• W2024776857 hasConceptScore W2024776857C167672396 @default.
• W2024776857 hasConceptScore W2024776857C203014093 @default.
• W2024776857 hasConceptScore W2024776857C2776090121 @default.
• W2024776857 hasConceptScore W2024776857C2779053233 @default.
• W2024776857 hasConceptScore W2024776857C2780801004 @default.
• W2024776857 hasConceptScore W2024776857C79484868 @default.
• W2024776857 hasConceptScore W2024776857C86803240 @default.
• W2024776857 hasConceptScore W2024776857C8891405 @default.
• W2024776857 hasIssue "23" @default.
• W2024776857 hasLocation W20247768571 @default.
• W2024776857 hasLocation W20247768572 @default.
• W2024776857 hasLocation W20247768573 @default.
• W2024776857 hasLocation W20247768574 @default.
• W2024776857 hasOpenAccess W2024776857 @default.
• W2024776857 hasPrimaryLocation W20247768571 @default.
• W2024776857 hasRelatedWork W1484759019 @default.
• W2024776857 hasRelatedWork W1485224098 @default.
• W2024776857 hasRelatedWork W2034807705 @default.
• W2024776857 hasRelatedWork W2040191638 @default.
• W2024776857 hasRelatedWork W2084199936 @default.
• W2024776857 hasRelatedWork W2220102944 @default.
• W2024776857 hasRelatedWork W2357951527 @default.
• W2024776857 hasRelatedWork W2392175816 @default.
• W2024776857 hasRelatedWork W2409441623 @default.
• W2024776857 hasRelatedWork W2903752946 @default.
• W2024776857 hasVolume "24" @default.

• next