Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024777100> ?p ?o ?g. }
- W2024777100 endingPage "926" @default.
- W2024777100 startingPage "915" @default.
- W2024777100 abstract "The aim of this review is to examine the evidence for a functional cholinergic system operating within the periodontium and determine the evidence for its role in periodontal immunity. Acetylcholine can influence the immune system via the ‘cholinergic anti-inflammatory pathway’. This pathway is mediated by the vagus nerve which releases acetylcholine to interact with the α7 subunit of the nicotinic acetylcholine receptor (α7nAChR) on proximate immuno-regulatory cells. Activation of the α7nAChR on these cells leads to down-regulated expression of pro-inflammatory mediators and thus regulates localised inflammatory responses. The role of the vagus nerve in periodontal pathophysiology is currently unknown. However, non-neuronal cells can also release acetylcholine and express the α7nAChR; these include keratinocytes, fibroblasts, T cells, B cells and macrophages. Therefore, by both autocrine and paracrine methods non-neuronal acetylcholine can also be hypothesised to modulate the localised immune response. A Pubmed database search was performed for studies providing evidence for a functional cholinergic system operating in the periodontium. In addition, literature on the role of the ‘cholinergic anti-inflammatory pathway’ in modulating the immune response was extrapolated to hypothesise that similar mechanisms of immune regulation occur within the periodontium. The evidence suggests a functional non-neuronal ‘cholinergic anti-inflammatory pathway’ may operate in the periodontium and that this may be targeted therapeutically to treat periodontal disease." @default.
- W2024777100 created "2016-06-24" @default.
- W2024777100 creator A5012250913 @default.
- W2024777100 creator A5013072298 @default.
- W2024777100 creator A5061473605 @default.
- W2024777100 date "2012-07-10" @default.
- W2024777100 modified "2023-10-14" @default.
- W2024777100 title "Acetylcholine and the alpha 7 nicotinic receptor: a potential therapeutic target for the treatment of periodontal disease?" @default.
- W2024777100 cites W1502233726 @default.
- W2024777100 cites W1550642465 @default.
- W2024777100 cites W1589489947 @default.
- W2024777100 cites W1594018550 @default.
- W2024777100 cites W1886401329 @default.
- W2024777100 cites W1908992399 @default.
- W2024777100 cites W1964544797 @default.
- W2024777100 cites W1981489754 @default.
- W2024777100 cites W1986356926 @default.
- W2024777100 cites W1986688861 @default.
- W2024777100 cites W1987096400 @default.
- W2024777100 cites W1987282235 @default.
- W2024777100 cites W2006346977 @default.
- W2024777100 cites W2007143131 @default.
- W2024777100 cites W2007188131 @default.
- W2024777100 cites W2011894887 @default.
- W2024777100 cites W2011895411 @default.
- W2024777100 cites W2018419151 @default.
- W2024777100 cites W2019025856 @default.
- W2024777100 cites W2026546195 @default.
- W2024777100 cites W2034471624 @default.
- W2024777100 cites W2034700053 @default.
- W2024777100 cites W2034753912 @default.
- W2024777100 cites W2035764211 @default.
- W2024777100 cites W2041258746 @default.
- W2024777100 cites W2042821764 @default.
- W2024777100 cites W2043393768 @default.
- W2024777100 cites W2044346996 @default.
- W2024777100 cites W2046083655 @default.
- W2024777100 cites W2047658647 @default.
- W2024777100 cites W2048238881 @default.
- W2024777100 cites W2049866461 @default.
- W2024777100 cites W2054543881 @default.
- W2024777100 cites W2059704497 @default.
- W2024777100 cites W2061026694 @default.
- W2024777100 cites W2063505951 @default.
- W2024777100 cites W2065853494 @default.
- W2024777100 cites W2069368135 @default.
- W2024777100 cites W2072649503 @default.
- W2024777100 cites W2073295417 @default.
- W2024777100 cites W2074733242 @default.
- W2024777100 cites W2075323804 @default.
- W2024777100 cites W2079644941 @default.
- W2024777100 cites W2082705025 @default.
- W2024777100 cites W2084055449 @default.
- W2024777100 cites W2090421556 @default.
- W2024777100 cites W2091840626 @default.
- W2024777100 cites W2093525797 @default.
- W2024777100 cites W2097391339 @default.
- W2024777100 cites W2099284983 @default.
- W2024777100 cites W2104838343 @default.
- W2024777100 cites W2111359173 @default.
- W2024777100 cites W2126343491 @default.
- W2024777100 cites W2128728122 @default.
- W2024777100 cites W2130514108 @default.
- W2024777100 cites W2131024082 @default.
- W2024777100 cites W2145080987 @default.
- W2024777100 cites W2154793521 @default.
- W2024777100 cites W2156897641 @default.
- W2024777100 cites W2157304646 @default.
- W2024777100 cites W2159995838 @default.
- W2024777100 cites W2169324938 @default.
- W2024777100 cites W2170822548 @default.
- W2024777100 cites W2285440636 @default.
- W2024777100 cites W2553315459 @default.
- W2024777100 cites W4240479957 @default.
- W2024777100 doi "https://doi.org/10.1007/s00011-012-0513-z" @default.
- W2024777100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3786254" @default.
- W2024777100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22777144" @default.
- W2024777100 hasPublicationYear "2012" @default.
- W2024777100 type Work @default.
- W2024777100 sameAs 2024777100 @default.
- W2024777100 citedByCount "22" @default.
- W2024777100 countsByYear W20247771002013 @default.
- W2024777100 countsByYear W20247771002014 @default.
- W2024777100 countsByYear W20247771002015 @default.
- W2024777100 countsByYear W20247771002016 @default.
- W2024777100 countsByYear W20247771002018 @default.
- W2024777100 countsByYear W20247771002019 @default.
- W2024777100 countsByYear W20247771002020 @default.
- W2024777100 countsByYear W20247771002021 @default.
- W2024777100 countsByYear W20247771002022 @default.
- W2024777100 countsByYear W20247771002023 @default.
- W2024777100 crossrefType "journal-article" @default.
- W2024777100 hasAuthorship W2024777100A5012250913 @default.
- W2024777100 hasAuthorship W2024777100A5013072298 @default.
- W2024777100 hasAuthorship W2024777100A5061473605 @default.
- W2024777100 hasBestOaLocation W20247771002 @default.
- W2024777100 hasConcept C126322002 @default.
- W2024777100 hasConcept C128240485 @default.