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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024777438> ?p ?o ?g. }

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• W2024777438 startingPage "327" @default.
• W2024777438 abstract "Acute inflammation of the sigmoid wall was induced by perendoscopic injection of formalin (50 μl, 5%) under brief anesthesia in rats. The procedure was followed by behavioral patterns that significantly differed from those in animals injected with isotonic saline instead of formalin. Analysis of the formalin-induced behaviors allowed for the calculation of a pain score that evolved in a biphasic manner along the 3 h of test. The score was dose-dependently reduced by morphine (0.5–4 mg/kg), and the analgesic effect of the largest morphine dose was abolished by naloxone (2.4 mg/kg). These results suggest that formalin into the sigmoid colon is a new model of visceral pain, presumably through direct irritation at injection site and/or localized acute inflammation of the intestinal wall." @default.
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• W2024777438 date "1994-06-01" @default.
• W2024777438 modified "2023-09-25" @default.
• W2024777438 title "Inflammation of the colonic wall induced by formalin as a model of acute visceral pain" @default.
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• W2024777438 doi "https://doi.org/10.1016/0304-3959(94)90008-6" @default.
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