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- W2024777512 abstract "Immunological studies in an 11-year-old patient with chronic mucocutaneous candidiasis are presented. Defective cellular immunity, both in vivo and in vitro, were identified. There was complete anergy, with negative intradermal tests for delayed hypersensitivity with eight antigens and a lack of response to dinitrochlorobenzene after contact sensitisation. A skin graft has not been rejected after more than a year. The patient's lymphocytes responded by proliferation in vitro to stimulation with phytohæmagglutinin, but not with mumps or monilia antigens. His cells neither responded nor stimulated in a one-way mixed lymphocyte culture. His serum inhibited the proliferative response of normal control lymphocytes stimulated with candida and mumps antigens, and allogeneic cells. These abnormal responses seem to be the result of the serum factor inhibiting the proliferative response of the small lymphocytes. The defect appears to be genetic, as there are other affected members in the family." @default.
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- W2024777512 date "1969-09-01" @default.
- W2024777512 modified "2023-09-26" @default.
- W2024777512 title "IMMUNOLOGICAL OBSERVATIONS IN CHRONIC MUCOCUTANEOUS CANDIDIASIS" @default.
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- W2024777512 doi "https://doi.org/10.1016/s0140-6736(69)90264-5" @default.
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