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- W2024778529 abstract "New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used to treat glaucoma) to afford ion pair (saline) species. The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for ocular drug delivery of carteolol to rabbits." @default.
- W2024778529 created "2016-06-24" @default.
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- W2024778529 date "2010-01-01" @default.
- W2024778529 modified "2023-10-17" @default.
- W2024778529 title "Designing dendrimers for ocular drug delivery" @default.
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- W2024778529 doi "https://doi.org/10.1016/j.ejmech.2009.10.017" @default.
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