FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024778918> ?p ?o ?g. }

• W2024778918 endingPage "2429" @default.
• W2024778918 startingPage "2420" @default.
• W2024778918 abstract "Tumor necrosis factor-alpha (TNF-α) is one major inflammatory factor peaking at 24 h after bone fracture in response to injury; its role in bone healing is controversial. The aims of this study were to investigate whether the duration of exposure to TNF-α is crucial for the initiation of bone regeneration and to determine its underlying mechanism(s). We demonstrated that 24 h of TNF-α treatment significantly abrogated osteocalcin gene expression by human primary osteoblasts (HOBs). However, when TNF-α was withdrawn after 24 h, bone sialoprotein and osteocalcin gene expression levels in HOBs at day 7 were significantly up-regulated compared with the HOBs without TNF-α treatment. In contrast, continuous TNF-α treatment down-regulated bone sialoprotein and osteocalcin gene expression. In addition, in an indirect co-culture system, HOBs pretreated with TNF-α for 24 h induced significantly greater osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (ASCs) than the HOBs without TNF-α treatment. TNF-α treatment also promoted endogenous bone morphogenetic protein 2 (BMP-2) production in HOBs, while blocking the BMP-2 signaling pathway with Noggin inhibited osteogenic differentiation of ASCs in the co-culture system. Furthermore, activation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway after TNF-α treatment occurred earlier than BMP-2 protein expression. BMP-2 production by HOBs and osteogenic differentiation of ASCs in the co-culture system with HOBs was significantly decreased when HOBs were pretreated with TNF-α in combination with the p38 MAPK-specific inhibitor (SB203580). Taken together, we provide evidence that exposure duration is a critical element in determining TNF-α's effects on bone regeneration. We also demonstrate that the p38 MAPK signaling pathway regulates the expression of BMP-2 in osteoblasts, which then acts through a paracrine loop, to direct the osteoblast lineage commitment of mesenchymal stem cells." @default.
• W2024778918 created "2016-06-24" @default.
• W2024778918 creator A5024297030 @default.
• W2024778918 creator A5059707523 @default.
• W2024778918 creator A5065350957 @default.
• W2024778918 creator A5090098460 @default.
• W2024778918 date "2012-09-01" @default.
• W2024778918 modified "2023-10-18" @default.
• W2024778918 title "Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation" @default.
• W2024778918 cites W1576481998 @default.
• W2024778918 cites W1607471435 @default.
• W2024778918 cites W1952701339 @default.
• W2024778918 cites W1967549460 @default.
• W2024778918 cites W1975156603 @default.
• W2024778918 cites W1980051005 @default.
• W2024778918 cites W1984743383 @default.
• W2024778918 cites W1986544619 @default.
• W2024778918 cites W1986973474 @default.
• W2024778918 cites W1988210099 @default.
• W2024778918 cites W1990820272 @default.
• W2024778918 cites W1991018493 @default.
• W2024778918 cites W1992712921 @default.
• W2024778918 cites W1995126981 @default.
• W2024778918 cites W2000851115 @default.
• W2024778918 cites W2005528887 @default.
• W2024778918 cites W2017720459 @default.
• W2024778918 cites W2019451761 @default.
• W2024778918 cites W2019881157 @default.
• W2024778918 cites W2020457805 @default.
• W2024778918 cites W2022346732 @default.
• W2024778918 cites W2024936019 @default.
• W2024778918 cites W2035406121 @default.
• W2024778918 cites W2036734184 @default.
• W2024778918 cites W2037503857 @default.
• W2024778918 cites W2040045796 @default.
• W2024778918 cites W2046607901 @default.
• W2024778918 cites W2053153924 @default.
• W2024778918 cites W2053837481 @default.
• W2024778918 cites W2060818104 @default.
• W2024778918 cites W2065415889 @default.
• W2024778918 cites W2069253007 @default.
• W2024778918 cites W2071582891 @default.
• W2024778918 cites W2075927574 @default.
• W2024778918 cites W2085627522 @default.
• W2024778918 cites W2086697911 @default.
• W2024778918 cites W2089224387 @default.
• W2024778918 cites W2099225289 @default.
• W2024778918 cites W2101921820 @default.
• W2024778918 cites W2106247097 @default.
• W2024778918 cites W2108879229 @default.
• W2024778918 cites W2113805413 @default.
• W2024778918 cites W2117599170 @default.
• W2024778918 cites W2123100180 @default.
• W2024778918 cites W2133819222 @default.
• W2024778918 cites W2145385610 @default.
• W2024778918 cites W2149369341 @default.
• W2024778918 cites W2161002542 @default.
• W2024778918 cites W2321156242 @default.
• W2024778918 cites W4243859586 @default.
• W2024778918 cites W4250465201 @default.
• W2024778918 doi "https://doi.org/10.1089/scd.2011.0589" @default.
• W2024778918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22296271" @default.
• W2024778918 hasPublicationYear "2012" @default.
• W2024778918 type Work @default.
• W2024778918 sameAs 2024778918 @default.
• W2024778918 citedByCount "64" @default.
• W2024778918 countsByYear W20247789182012 @default.
• W2024778918 countsByYear W20247789182013 @default.
• W2024778918 countsByYear W20247789182014 @default.
• W2024778918 countsByYear W20247789182015 @default.
• W2024778918 countsByYear W20247789182016 @default.
• W2024778918 countsByYear W20247789182017 @default.
• W2024778918 countsByYear W20247789182018 @default.
• W2024778918 countsByYear W20247789182019 @default.
• W2024778918 countsByYear W20247789182020 @default.
• W2024778918 countsByYear W20247789182021 @default.
• W2024778918 countsByYear W20247789182022 @default.
• W2024778918 countsByYear W20247789182023 @default.
• W2024778918 crossrefType "journal-article" @default.
• W2024778918 hasAuthorship W2024778918A5024297030 @default.
• W2024778918 hasAuthorship W2024778918A5059707523 @default.
• W2024778918 hasAuthorship W2024778918A5065350957 @default.
• W2024778918 hasAuthorship W2024778918A5090098460 @default.
• W2024778918 hasConcept C104317684 @default.
• W2024778918 hasConcept C126322002 @default.
• W2024778918 hasConcept C131075544 @default.
• W2024778918 hasConcept C134018914 @default.
• W2024778918 hasConcept C160160445 @default.
• W2024778918 hasConcept C171089720 @default.
• W2024778918 hasConcept C17991360 @default.
• W2024778918 hasConcept C181199279 @default.
• W2024778918 hasConcept C198826908 @default.
• W2024778918 hasConcept C202751555 @default.
• W2024778918 hasConcept C2776432469 @default.
• W2024778918 hasConcept C30352789 @default.
• W2024778918 hasConcept C31507581 @default.
• W2024778918 hasConcept C502942594 @default.
• W2024778918 hasConcept C55493867 @default.

• next