FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024781408> ?p ?o ?g. }

• W2024781408 endingPage "e69299" @default.
• W2024781408 startingPage "e69299" @default.
• W2024781408 abstract "Lung diseases are a major cause of global morbidity and mortality that are treated with limited efficacy. Recently stem cell therapies have been shown to effectively treat animal models of lung disease. However, there are limitations to the translation of these cell therapies to clinical disease. Studies have shown that delayed treatment of animal models does not improve outcomes and that the models do not reflect the repeated injury that is present in most lung diseases. We tested the efficacy of amnion mesenchymal stem cells (AM-MSC), bone marrow MSC (BM-MSC) and human amniotic epithelial cells (hAEC) in C57BL/6 mice using a repeat dose bleomycin-induced model of lung injury that better reflects the repeat injury seen in lung diseases. The dual bleomycin dose led to significantly higher levels of inflammation and fibrosis in the mouse lung compared to a single bleomycin dose. Intravenously infused stem cells were present in the lung in similar numbers at days 7 and 21 post cell injection. In addition, stem cell injection resulted in a significant decrease in inflammatory cell infiltrate and a reduction in IL-1 (AM-MSC), IL-6 (AM-MSC, BM-MSC, hAEC) and TNF-α (AM-MSC). The only trophic factor tested that increased following stem cell injection was IL-1RA (AM-MSC). IL-1RA levels may be modulated by GM-CSF produced by AM-MSC. Furthermore, only AM-MSC reduced collagen deposition and increased MMP-9 activity in the lung although there was a reduction of the pro-fibrogenic cytokine TGF-β following BM-MSC, AM-MSC and hAEC treatment. Therefore, AM-MSC may be more effective in reducing injury following delayed injection in the setting of repeated lung injury." @default.
• W2024781408 created "2016-06-24" @default.
• W2024781408 creator A5006102759 @default.
• W2024781408 creator A5008749184 @default.
• W2024781408 creator A5017774512 @default.
• W2024781408 creator A5019105173 @default.
• W2024781408 creator A5024499949 @default.
• W2024781408 creator A5029379615 @default.
• W2024781408 creator A5042431804 @default.
• W2024781408 creator A5065411322 @default.
• W2024781408 creator A5083485144 @default.
• W2024781408 creator A5085975673 @default.
• W2024781408 date "2013-08-01" @default.
• W2024781408 modified "2023-09-30" @default.
• W2024781408 title "Anti-Inflammatory Effects of Adult Stem Cells in Sustained Lung Injury: A Comparative Study" @default.
• W2024781408 cites W1548867065 @default.
• W2024781408 cites W1964464065 @default.
• W2024781408 cites W1973009130 @default.
• W2024781408 cites W1984560751 @default.
• W2024781408 cites W1987558037 @default.
• W2024781408 cites W1989735558 @default.
• W2024781408 cites W1994661247 @default.
• W2024781408 cites W1997470313 @default.
• W2024781408 cites W2004803235 @default.
• W2024781408 cites W2016859011 @default.
• W2024781408 cites W2027162413 @default.
• W2024781408 cites W2028702444 @default.
• W2024781408 cites W2029844302 @default.
• W2024781408 cites W2038113465 @default.
• W2024781408 cites W2046215712 @default.
• W2024781408 cites W2046237540 @default.
• W2024781408 cites W2052027903 @default.
• W2024781408 cites W2053653008 @default.
• W2024781408 cites W2062101834 @default.
• W2024781408 cites W2073292917 @default.
• W2024781408 cites W2075400164 @default.
• W2024781408 cites W2079363030 @default.
• W2024781408 cites W2083769234 @default.
• W2024781408 cites W2092892225 @default.
• W2024781408 cites W2101064515 @default.
• W2024781408 cites W2101116554 @default.
• W2024781408 cites W2112161526 @default.
• W2024781408 cites W2115871198 @default.
• W2024781408 cites W2116341181 @default.
• W2024781408 cites W2117918359 @default.
• W2024781408 cites W2128267813 @default.
• W2024781408 cites W2133375451 @default.
• W2024781408 cites W2139519365 @default.
• W2024781408 cites W2150103989 @default.
• W2024781408 cites W2155254073 @default.
• W2024781408 cites W2161006376 @default.
• W2024781408 cites W2333140339 @default.
• W2024781408 doi "https://doi.org/10.1371/journal.pone.0069299" @default.
• W2024781408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731305" @default.
• W2024781408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23936322" @default.
• W2024781408 hasPublicationYear "2013" @default.
• W2024781408 type Work @default.
• W2024781408 sameAs 2024781408 @default.
• W2024781408 citedByCount "86" @default.
• W2024781408 countsByYear W20247814082014 @default.
• W2024781408 countsByYear W20247814082015 @default.
• W2024781408 countsByYear W20247814082016 @default.
• W2024781408 countsByYear W20247814082017 @default.
• W2024781408 countsByYear W20247814082018 @default.
• W2024781408 countsByYear W20247814082019 @default.
• W2024781408 countsByYear W20247814082020 @default.
• W2024781408 countsByYear W20247814082021 @default.
• W2024781408 countsByYear W20247814082022 @default.
• W2024781408 countsByYear W20247814082023 @default.
• W2024781408 crossrefType "journal-article" @default.
• W2024781408 hasAuthorship W2024781408A5006102759 @default.
• W2024781408 hasAuthorship W2024781408A5008749184 @default.
• W2024781408 hasAuthorship W2024781408A5017774512 @default.
• W2024781408 hasAuthorship W2024781408A5019105173 @default.
• W2024781408 hasAuthorship W2024781408A5024499949 @default.
• W2024781408 hasAuthorship W2024781408A5029379615 @default.
• W2024781408 hasAuthorship W2024781408A5042431804 @default.
• W2024781408 hasAuthorship W2024781408A5065411322 @default.
• W2024781408 hasAuthorship W2024781408A5083485144 @default.
• W2024781408 hasAuthorship W2024781408A5085975673 @default.
• W2024781408 hasBestOaLocation W20247814081 @default.
• W2024781408 hasConcept C10882517 @default.
• W2024781408 hasConcept C126322002 @default.
• W2024781408 hasConcept C142724271 @default.
• W2024781408 hasConcept C198826908 @default.
• W2024781408 hasConcept C203014093 @default.
• W2024781408 hasConcept C2776232574 @default.
• W2024781408 hasConcept C2776694085 @default.
• W2024781408 hasConcept C2776914184 @default.
• W2024781408 hasConcept C2777714996 @default.
• W2024781408 hasConcept C2778690821 @default.
• W2024781408 hasConcept C2779389132 @default.
• W2024781408 hasConcept C2780007613 @default.
• W2024781408 hasConcept C2780559512 @default.
• W2024781408 hasConcept C28328180 @default.
• W2024781408 hasConcept C54355233 @default.
• W2024781408 hasConcept C71924100 @default.
• W2024781408 hasConcept C86803240 @default.

• next