FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024786180> ?p ?o ?g. }

• W2024786180 endingPage "326" @default.
• W2024786180 startingPage "289" @default.
• W2024786180 abstract "We present de novo studies and review published efforts from our laboratory, spanning 12 years (from 1988 to 2000), where we have used ultrastructural approaches to study the functional anatomy of the microvasculature in man and animals in health and disease. These efforts have defined a new endothelial cell organelle, termed the vesiculo-vacuolar organelle (VVO), which participates in the regulated transendothelial cell passage of soluble macromolecules. The studies defining this organelle utilized ultrathin serial sections, three-dimensional computer-assisted reconstructions, and ultrastructural electron-dense tracers to establish luminal to abluminal transendothelial cell continuity of VVOs. Commonality of VVOs and caveolae is suggested by the ultrastructural anatomy of individual units of VVOs and caveolae, the presence of caveolin in both structures, and a mathematical analysis of morphometric data, all of which suggest that VVOs form from fusions of individual size units equivalent to vesicles of caveolar size. Ultrastructural studies have localized potent permeability factors and their specific receptors to VVOs in in vivo tumor and allergic inflammation models. Regulation of permeability through VVOs has been quantified and shown to be increased in tumor microvessels and in control vessels exposed to potent permeability-inducing mediators. The transendothelial cell passage of particulate macromolecules occurs by vacuolar transport in tumor vessels; in permeability factor-exposed control vessels, colloidal carbon traversed endothelial cells via the development of pores that did not communicate with or disrupt intercellular junctions by gap formation. Serial section and computer-assisted reconstructions established these findings and suggested the possible development of transendothelial cell pores from VVOs. Serial sectioning and computer-assisted three-dimensional reconstructions of ultrastructural samples of an acute inflammation model revealed a transendothelial cell traffic route for motile neutrophils and platelets in the absence of classical ultrastructural criteria for regulated secretion from either cell. Microsc. Res. Tech. 57:289–326, 2002. © 2002 Wiley-Liss, Inc." @default.
• W2024786180 created "2016-06-24" @default.
• W2024786180 creator A5007150862 @default.
• W2024786180 creator A5025926408 @default.
• W2024786180 creator A5058290100 @default.
• W2024786180 creator A5059154238 @default.
• W2024786180 date "2002-05-22" @default.
• W2024786180 modified "2023-09-25" @default.
• W2024786180 title "Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals" @default.
• W2024786180 cites W1537048284 @default.
• W2024786180 cites W1556110303 @default.
• W2024786180 cites W1557964895 @default.
• W2024786180 cites W1905486804 @default.
• W2024786180 cites W1913982549 @default.
• W2024786180 cites W1966781899 @default.
• W2024786180 cites W1969222099 @default.
• W2024786180 cites W1971248512 @default.
• W2024786180 cites W1972438151 @default.
• W2024786180 cites W1974043466 @default.
• W2024786180 cites W1974679277 @default.
• W2024786180 cites W1974964684 @default.
• W2024786180 cites W1977712239 @default.
• W2024786180 cites W1980755389 @default.
• W2024786180 cites W1980776868 @default.
• W2024786180 cites W1981612052 @default.
• W2024786180 cites W1982918107 @default.
• W2024786180 cites W1983763042 @default.
• W2024786180 cites W1983949401 @default.
• W2024786180 cites W1985700920 @default.
• W2024786180 cites W1985712533 @default.
• W2024786180 cites W1996247217 @default.
• W2024786180 cites W1997749867 @default.
• W2024786180 cites W1997760135 @default.
• W2024786180 cites W2001668786 @default.
• W2024786180 cites W2001952162 @default.
• W2024786180 cites W2003598961 @default.
• W2024786180 cites W2004554331 @default.
• W2024786180 cites W2006387884 @default.
• W2024786180 cites W2008455568 @default.
• W2024786180 cites W2011244385 @default.
• W2024786180 cites W2012690424 @default.
• W2024786180 cites W2014230177 @default.
• W2024786180 cites W2018646338 @default.
• W2024786180 cites W2020502307 @default.
• W2024786180 cites W2023453327 @default.
• W2024786180 cites W2025745642 @default.
• W2024786180 cites W2025933554 @default.
• W2024786180 cites W2027802458 @default.
• W2024786180 cites W2029265259 @default.
• W2024786180 cites W2030085176 @default.
• W2024786180 cites W2031472030 @default.
• W2024786180 cites W2032169257 @default.
• W2024786180 cites W2034231380 @default.
• W2024786180 cites W2034363142 @default.
• W2024786180 cites W2035371785 @default.
• W2024786180 cites W2036127937 @default.
• W2024786180 cites W2038496502 @default.
• W2024786180 cites W2041019461 @default.
• W2024786180 cites W2042900542 @default.
• W2024786180 cites W2048185125 @default.
• W2024786180 cites W2049827480 @default.
• W2024786180 cites W2050027980 @default.
• W2024786180 cites W2050465028 @default.
• W2024786180 cites W2052398489 @default.
• W2024786180 cites W2057083972 @default.
• W2024786180 cites W2060484953 @default.
• W2024786180 cites W2061742917 @default.
• W2024786180 cites W2062594120 @default.
• W2024786180 cites W2064973401 @default.
• W2024786180 cites W2068908631 @default.
• W2024786180 cites W2069444054 @default.
• W2024786180 cites W2070335877 @default.
• W2024786180 cites W2070541243 @default.
• W2024786180 cites W2071605333 @default.
• W2024786180 cites W2071872174 @default.
• W2024786180 cites W2073848307 @default.
• W2024786180 cites W2078587019 @default.
• W2024786180 cites W2081513562 @default.
• W2024786180 cites W2083126720 @default.
• W2024786180 cites W2084506573 @default.
• W2024786180 cites W2091263537 @default.
• W2024786180 cites W2091898459 @default.
• W2024786180 cites W2093336596 @default.
• W2024786180 cites W2094104389 @default.
• W2024786180 cites W2099096390 @default.
• W2024786180 cites W2101228903 @default.
• W2024786180 cites W2102067917 @default.
• W2024786180 cites W2104901638 @default.
• W2024786180 cites W2117468682 @default.
• W2024786180 cites W2119311154 @default.
• W2024786180 cites W2120190211 @default.
• W2024786180 cites W2120372571 @default.
• W2024786180 cites W2126249291 @default.
• W2024786180 cites W2129179416 @default.
• W2024786180 cites W2137845396 @default.
• W2024786180 cites W2138120258 @default.
• W2024786180 cites W2140082856 @default.
• W2024786180 cites W2140612321 @default.

• next