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• W2024786312 endingPage "37479" @default.
• W2024786312 startingPage "37471" @default.
• W2024786312 abstract "Genes positioned close to telomeres in yeast are silenced by a heterochromatin-like structure containing Sir proteins. To investigate whether silencing also affects DNA repair, we studied removal of UV lesions by photolyase and nucleotide excision repair (NER) in strains containing the <i>URA3</i> gene inserted 2 kilobases from a telomere. <i>URA3</i> was transcriptionally active in <i>sir3</i>Δ mutants, partially silenced in <i>SIR3</i> cells, or completely silenced by overexpression of <i>SIR3</i> or deletion of <i>RPD3</i>. The active <i>URA3</i> showed efficient repair by both pathways. Fast repair of the promoter and 3′ end by photolyase reflected a non-nucleosomal structure. Partial silencing had no remarkable effect on photolyase but reduced repair by NER, indicating differential accessibility for the two repair reactions. Complete silencing inhibits NER and photolyase in the coding region as well as in the promoter and the 3′-end. Conventional nuclease footprinting analyses revealed subtle changes in the promoter proximal nucleosome under partially silenced conditions but a pronounced reorganization of chromatin extending over the whole gene in silenced chromatin. Thus, both repair systems are sensitive to chromatin changes associated with silencing and provide direct evidence for a compact structure of heterochromatin." @default.
• W2024786312 created "2016-06-24" @default.
• W2024786312 creator A5001350324 @default.
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• W2024786312 creator A5090116946 @default.
• W2024786312 date "2003-09-01" @default.
• W2024786312 modified "2023-10-17" @default.
• W2024786312 title "Repair of UV Lesions in Silenced Chromatin Provides in Vivo Evidence for a Compact Chromatin Structure" @default.
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• W2024786312 doi "https://doi.org/10.1074/jbc.m306335200" @default.
• W2024786312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12882973" @default.
• W2024786312 hasPublicationYear "2003" @default.
• W2024786312 type Work @default.

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