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- W2024792371 abstract "The effect of norethandrolone (17α-ethyl-19-nortestosterone) on the epiphyseal cartilage of rachitic chicks was investigated in conjunction with the studies of vitamin D 3 effect on this tissue. Norethandrolone effected a significant decrease in the activity of hexosamine synthetase, but did not alter appreciably the levels of hexosamine or hydroxyproline, nor the activity of alkaline phosphatase.It was noted that norethandrolone exerted a powerful stimulation on the growth of combs of immature chicks. The increased weight of the combs was accompanied by a higher water content. The de-fatted and dried fraction of these combs had an elevated content of hexosamines, while the decrease in hydroxyproline content was noted only after a prolonged treatment with the steroid. Studies with radioactive tracers (Na 2 S 35 O 4 , NaOAc-1-C 14 ) showed an increased rate of incorporation of these potential components of glycosaminoglycans in the de-fatted and dried fraction of the combs. In addition, norethandrolone enhanced the alkaline phosphatase activity in combs." @default.
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- W2024792371 date "1965-08-01" @default.
- W2024792371 modified "2023-10-10" @default.
- W2024792371 title "EFFECT OF NORETHANDROLONE ON SELECTED CONNECTIVE TISSUES" @default.
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- W2024792371 doi "https://doi.org/10.1139/o65-135" @default.
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