FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024792684> ?p ?o ?g. }

• W2024792684 endingPage "499" @default.
• W2024792684 startingPage "479" @default.
• W2024792684 abstract "The negative steady potential (SP) shift associated with the direct cortical response (evoked by slow repetitive stimulation) is believed to be generated by glial depolarization secondary to a transient increase in [K+0. This SP shift is augmented by barbiturate and reduced by procaine. To elucidate these drug effects the direct cortical response was studied simultaneously with intracellular recording from glia in one group of experiments and with measurements of [K+0 in another. Barbiturate produced the expected increase in the negative SP shift, but had either no effect, or slightly reduced glial slow depolarization (SD). The effect on [K+o was similar. These findings argue against glial SD as being the only source of the SP shift during barbiturate anesthesia and suggest a significant neuronal contribution. That this is so is strongly suggested by finding a reversal in polarity of the barbiturate augmented negative SP shift, 600–900 μm below the cortical surface. This reversal is expected for a potential generated by vertically oriented neurons and differs from the situation before barbiturate administration when the SP shift does not reverse but becomes progressively smaller in the cortical depth, consistent with a glial origin for the SP shift. With procaine, the SP shift and SD are modified similarly. They both undergo a quantitatively appropriate amplitude reduction. The effect of procaine on [K+0 could not be tested since procaine directly effects ion-sensitive K+ electrodes. Laminar analysis of the reduced negative SP shift after procaine is qualitatively similar to the finding before giving the drug; there is no reversal. We believe the reduced SP shift after procaine continues to reflect glial SD. Procaine can diminish both direct and synaptic neural excitation which would result in a smaller extracellular liberation of K+ and hence a smaller glial SD and SP shift. By contrast, barbiturate which can also depress synaptic excitation is believed, in addition, to uncover and enhance (especially by prolongation) postsynaptic inhibition. Thus, after barbiturate, the augmented SP shift may reflect the addition of two separately generated surface negatives—glial SD and summated hyperpolarizing IPSPs in cortical depth." @default.
• W2024792684 created "2016-06-24" @default.
• W2024792684 creator A5037746759 @default.
• W2024792684 creator A5043231922 @default.
• W2024792684 creator A5046325285 @default.
• W2024792684 creator A5059803746 @default.
• W2024792684 date "1977-10-01" @default.
• W2024792684 modified "2023-09-26" @default.
• W2024792684 title "The effect of barbiturate and procaine in glial and neuronal contributions to evoked cortical steady potential shifts" @default.
• W2024792684 cites W1849732852 @default.
• W2024792684 cites W1864765563 @default.
• W2024792684 cites W1939037149 @default.
• W2024792684 cites W1957054215 @default.
• W2024792684 cites W1964083428 @default.
• W2024792684 cites W1968145606 @default.
• W2024792684 cites W1971576248 @default.
• W2024792684 cites W1975293359 @default.
• W2024792684 cites W1978329654 @default.
• W2024792684 cites W1982734464 @default.
• W2024792684 cites W1998266315 @default.
• W2024792684 cites W2010762539 @default.
• W2024792684 cites W2011198767 @default.
• W2024792684 cites W2012940616 @default.
• W2024792684 cites W2014783850 @default.
• W2024792684 cites W2029987436 @default.
• W2024792684 cites W2031577071 @default.
• W2024792684 cites W2032384871 @default.
• W2024792684 cites W2032745984 @default.
• W2024792684 cites W2038588622 @default.
• W2024792684 cites W2049221751 @default.
• W2024792684 cites W2061148843 @default.
• W2024792684 cites W2066774251 @default.
• W2024792684 cites W2075929625 @default.
• W2024792684 cites W2076182258 @default.
• W2024792684 cites W2078781755 @default.
• W2024792684 cites W2078963381 @default.
• W2024792684 cites W2084659149 @default.
• W2024792684 cites W2087670973 @default.
• W2024792684 cites W2094428417 @default.
• W2024792684 cites W2104038573 @default.
• W2024792684 cites W2233187579 @default.
• W2024792684 cites W2279980834 @default.
• W2024792684 cites W2341541642 @default.
• W2024792684 cites W2394878837 @default.
• W2024792684 cites W2405757777 @default.
• W2024792684 cites W2412812625 @default.
• W2024792684 cites W4214935389 @default.
• W2024792684 cites W4234390024 @default.
• W2024792684 doi "https://doi.org/10.1016/0006-8993(77)90824-1" @default.
• W2024792684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/902111" @default.
• W2024792684 hasPublicationYear "1977" @default.
• W2024792684 type Work @default.
• W2024792684 sameAs 2024792684 @default.
• W2024792684 citedByCount "10" @default.
• W2024792684 crossrefType "journal-article" @default.
• W2024792684 hasAuthorship W2024792684A5037746759 @default.
• W2024792684 hasAuthorship W2024792684A5043231922 @default.
• W2024792684 hasAuthorship W2024792684A5046325285 @default.
• W2024792684 hasAuthorship W2024792684A5059803746 @default.
• W2024792684 hasConcept C12554922 @default.
• W2024792684 hasConcept C169760540 @default.
• W2024792684 hasConcept C185263204 @default.
• W2024792684 hasConcept C185592680 @default.
• W2024792684 hasConcept C24998067 @default.
• W2024792684 hasConcept C2779828710 @default.
• W2024792684 hasConcept C2780077838 @default.
• W2024792684 hasConcept C4141045 @default.
• W2024792684 hasConcept C42219234 @default.
• W2024792684 hasConcept C71924100 @default.
• W2024792684 hasConcept C86803240 @default.
• W2024792684 hasConceptScore W2024792684C12554922 @default.
• W2024792684 hasConceptScore W2024792684C169760540 @default.
• W2024792684 hasConceptScore W2024792684C185263204 @default.
• W2024792684 hasConceptScore W2024792684C185592680 @default.
• W2024792684 hasConceptScore W2024792684C24998067 @default.
• W2024792684 hasConceptScore W2024792684C2779828710 @default.
• W2024792684 hasConceptScore W2024792684C2780077838 @default.
• W2024792684 hasConceptScore W2024792684C4141045 @default.
• W2024792684 hasConceptScore W2024792684C42219234 @default.
• W2024792684 hasConceptScore W2024792684C71924100 @default.
• W2024792684 hasConceptScore W2024792684C86803240 @default.
• W2024792684 hasIssue "3" @default.
• W2024792684 hasLocation W20247926841 @default.
• W2024792684 hasLocation W20247926842 @default.
• W2024792684 hasOpenAccess W2024792684 @default.
• W2024792684 hasPrimaryLocation W20247926841 @default.
• W2024792684 hasRelatedWork W1614088124 @default.
• W2024792684 hasRelatedWork W1990715845 @default.
• W2024792684 hasRelatedWork W1999282796 @default.
• W2024792684 hasRelatedWork W2019230051 @default.
• W2024792684 hasRelatedWork W2063749801 @default.
• W2024792684 hasRelatedWork W2067697666 @default.
• W2024792684 hasRelatedWork W2070602124 @default.
• W2024792684 hasRelatedWork W2095283181 @default.
• W2024792684 hasRelatedWork W2256350618 @default.
• W2024792684 hasRelatedWork W2292840910 @default.
• W2024792684 hasVolume "134" @default.
• W2024792684 isParatext "false" @default.

• next