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• W2024793020 startingPage "2757" @default.
• W2024793020 abstract "Peripheral blood mononuclear cells from pregnant and postpartum women were cultured in vitro with erythropoietin. Burst-forming unit (BFU-E)-derived erythroid colonies composed of immature erythroblasts with low hemoglobin contents were observed by day 8 of culture. By day 12 of culture, numerous BFU-E-derived erythroid colonies with high hemoglobin contents were present. The gamma/(gamma + beta) globin synthetic ratio was approximately 12% in the early cultures and 6% in the late cultures, indicating that the proportion of fetal hemoglobin synthesis decreases during erythroid cell maturation. These studies also reveal that the capacity fof fetal hemoglobin production by peripheral blood BFU-E in vitro is not altered during pregnancy." @default.
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• W2024793020 date "1980-05-01" @default.
• W2024793020 modified "2023-09-29" @default.
• W2024793020 title "Proportion of fetal hemoglobin synthesis decreases during erythroid cell maturation." @default.
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• W2024793020 doi "https://doi.org/10.1073/pnas.77.5.2757" @default.
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