FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024793489> ?p ?o ?g. }

• W2024793489 endingPage "182" @default.
• W2024793489 startingPage "171" @default.
• W2024793489 abstract "Cytoplasmic protein tyrosine kinases of the Src family play a pivotal role in the regulation of cellular processes including proliferation and differentiation. Among other functions, Src kinases are involved in regulating the cell architecture. In an approach to identify protein tyrosine kinases from the medically important parasite Schistosoma mansoni, we isolated the TK3 gene by degenerate primer PCR and cDNA library screening. Sequencing of the complete cDNA and data-base analyses indicated that TK3 is a Src family kinase. Its predicted size of 71 kDa was confirmed by Western blot analysis. Southern blot analysis showed that TK3 is a single-copy gene, and Northern blot and RT-PCR experiments indicated its expression in both sexes and throughout development. Localization studies by in situ hybridization and immunolocalization revealed that TK3 is predominantly expressed in the reproductive organs such as the testes of the male and the ovary as well as the vitellarium of the female. Its enzymatic activity was confirmed by functional analyses. In transient transfection experiments with HEK293 cells, TK3 phosphorylated the well-known Src-kinase substrate p130 Cas, an intracellular scaffolding protein. Yeast two-hybrid screenings in a heterologous invertebrate system identified dAbi, vinculin and tubulin as binding partners, representing molecules that fulfill functions in the cell architecture of many organisms. These findings suggest that TK3 may play a role in signal transduction pathways organizing the cytoskeleton in the gonads of schistosomes." @default.
• W2024793489 created "2016-06-24" @default.
• W2024793489 creator A5004611724 @default.
• W2024793489 creator A5007668496 @default.
• W2024793489 creator A5009223732 @default.
• W2024793489 creator A5036212175 @default.
• W2024793489 creator A5044780249 @default.
• W2024793489 creator A5057502869 @default.
• W2024793489 creator A5064789008 @default.
• W2024793489 date "2004-12-01" @default.
• W2024793489 modified "2023-09-28" @default.
• W2024793489 title "The Schistosoma mansoni Src kinase TK3 is expressed in the gonads and likely involved in cytoskeletal organization" @default.
• W2024793489 cites W1512355975 @default.
• W2024793489 cites W1565513363 @default.
• W2024793489 cites W1900495018 @default.
• W2024793489 cites W1913862483 @default.
• W2024793489 cites W1954929088 @default.
• W2024793489 cites W1969214447 @default.
• W2024793489 cites W1970467164 @default.
• W2024793489 cites W1976214697 @default.
• W2024793489 cites W1979762964 @default.
• W2024793489 cites W1984730989 @default.
• W2024793489 cites W1985127246 @default.
• W2024793489 cites W1992659479 @default.
• W2024793489 cites W2003481405 @default.
• W2024793489 cites W2004587190 @default.
• W2024793489 cites W2006300406 @default.
• W2024793489 cites W2008435836 @default.
• W2024793489 cites W2018293082 @default.
• W2024793489 cites W2020257412 @default.
• W2024793489 cites W2020383520 @default.
• W2024793489 cites W2020486934 @default.
• W2024793489 cites W2030112336 @default.
• W2024793489 cites W2031261700 @default.
• W2024793489 cites W2032062053 @default.
• W2024793489 cites W2042269004 @default.
• W2024793489 cites W2054828855 @default.
• W2024793489 cites W2055219936 @default.
• W2024793489 cites W2063259786 @default.
• W2024793489 cites W2064883409 @default.
• W2024793489 cites W2072300163 @default.
• W2024793489 cites W2078827095 @default.
• W2024793489 cites W2079051863 @default.
• W2024793489 cites W2082635264 @default.
• W2024793489 cites W2084523020 @default.
• W2024793489 cites W2086098969 @default.
• W2024793489 cites W2090634323 @default.
• W2024793489 cites W2093662358 @default.
• W2024793489 cites W2101173100 @default.
• W2024793489 cites W2101257013 @default.
• W2024793489 cites W2108329503 @default.
• W2024793489 cites W2115491202 @default.
• W2024793489 cites W2121905156 @default.
• W2024793489 cites W2125269810 @default.
• W2024793489 cites W2132488847 @default.
• W2024793489 cites W2137799271 @default.
• W2024793489 cites W2138067522 @default.
• W2024793489 cites W2138185230 @default.
• W2024793489 cites W2142249251 @default.
• W2024793489 cites W2164782544 @default.
• W2024793489 cites W2168547874 @default.
• W2024793489 cites W2168847939 @default.
• W2024793489 cites W2175144456 @default.
• W2024793489 cites W2189076266 @default.
• W2024793489 cites W2341436783 @default.
• W2024793489 cites W2397518918 @default.
• W2024793489 cites W4211075026 @default.
• W2024793489 doi "https://doi.org/10.1016/j.molbiopara.2004.07.010" @default.
• W2024793489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15555729" @default.
• W2024793489 hasPublicationYear "2004" @default.
• W2024793489 type Work @default.
• W2024793489 sameAs 2024793489 @default.
• W2024793489 citedByCount "49" @default.
• W2024793489 countsByYear W20247934892012 @default.
• W2024793489 countsByYear W20247934892013 @default.
• W2024793489 countsByYear W20247934892014 @default.
• W2024793489 countsByYear W20247934892015 @default.
• W2024793489 countsByYear W20247934892016 @default.
• W2024793489 countsByYear W20247934892017 @default.
• W2024793489 countsByYear W20247934892018 @default.
• W2024793489 countsByYear W20247934892019 @default.
• W2024793489 countsByYear W20247934892020 @default.
• W2024793489 countsByYear W20247934892021 @default.
• W2024793489 countsByYear W20247934892022 @default.
• W2024793489 crossrefType "journal-article" @default.
• W2024793489 hasAuthorship W2024793489A5004611724 @default.
• W2024793489 hasAuthorship W2024793489A5007668496 @default.
• W2024793489 hasAuthorship W2024793489A5009223732 @default.
• W2024793489 hasAuthorship W2024793489A5036212175 @default.
• W2024793489 hasAuthorship W2024793489A5044780249 @default.
• W2024793489 hasAuthorship W2024793489A5057502869 @default.
• W2024793489 hasAuthorship W2024793489A5064789008 @default.
• W2024793489 hasConcept C104317684 @default.
• W2024793489 hasConcept C108636557 @default.
• W2024793489 hasConcept C153911025 @default.
• W2024793489 hasConcept C165901193 @default.
• W2024793489 hasConcept C177707886 @default.
• W2024793489 hasConcept C184235292 @default.

• next