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• W2024794847 abstract "The activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were increased in the superior cervical ganglion of the rat between 2 and 7 days after sectioning the major postganglionic nerve trunks of the ganglion. Both enzymes returned to normal levels at 10 days after axotomy. Microscopic and quantitative histochemical analyses demonstrated that these changes in the 2 oxidative enzymes of the pentose phosphate pathway occurred in chromatolytic cells in the cranial pole of axotomized ganglia. Transketolase was slightly reduced at 2, 7 and 10 days after axotomy in this region which contains the majority of the chromatolytic cells. No significant changes were observed in the activities of NADP+-dependent isocitrate dehydrogenase, malic enzyme, transketolase or ribose-5-phosphate isomerase in homogenates of axotomized ganglia as compared to those of the contralateral normal (sham-operated) ganglia. Administration of 6-aminonicotinamide (6-AN) to rats resulted in a marked accumulation of 6-phosphogluconate in both normal and axotomized ganglia, confirming that the oxidative portion of the pentose phosphate pathway is active in these tissuesin vivo. From the rate at which 6-phosphogluconate accumulated in ganglia of 6-AN-treated rats it was estimated that at least 16% of the glucose metabolism of the ganglion occurs via this pathway under resting conditions. Oxidation of [1-14C]glucose and [6-14C]glucose to14CO2 in normal and axotomized ganglia was observedin vitro 2 days after nerve section. Metabolism of [1-14C]glucose to14CO2 as well as the ratio of [1-14C]glucose: [6-14C]glucose converted to14CO2 were greater in axotomized than in contralateral normal ganglia. Thus, the increases in the oxidative enzymes of the pentose phosphate pathway in the axotomized ganglion appear to be associated with increased metabolism via this pathway. Activation of the pentose phosphate pathway in the axotomized ganglion was temporally correlated with early increases in lipid and RNA in the ganglion and other types of axotomized nerve cells. It is concluded that an important relationship may exist between metabolism via the oxidative enzymes of the pentose phosphate pathway and biosynthetic events during the early period of nerve regeneration." @default.
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• W2024794847 date "1974-01-01" @default.
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• W2024794847 title "Metabolic alterations in the axotomized superior cervical ganglion of the rat. II. The pentose phosphate pathway" @default.
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• W2024794847 doi "https://doi.org/10.1016/0006-8993(74)90341-2" @default.
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