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• W2024795009 abstract "Mesangial cell (MC) proliferation and the deposition of collagen type I (collagen I) are the major pathological features in many types of glomerulonephritis (GN). Recent work suggested that β-integrins play a critical role in the cell proliferation and extracellular matrix (ECM) remodeling observed in tissue repair after injury. To examine the involvement of β-integrins in MC proliferation in association with the interaction of MCs with pathological collagen I, we investigated the effect of a prominent mitogen, platelet-derived growth factor-BB (PDGF-BB) on the growth and expression of β-integrins by MCs cultured on plastic or in a three-dimensional collagen I gel. Immunoprecipitation using35S-metabolic labeling, flow cytometry and a3H-thymidine-uptake analysis demonstrated that PDGF-BB stimulated the cell mitogenicity and the expression of α5β1 integrin (a fibronectin receptor), but not α1β1 integrin (a collagen and laminin receptor) of MCs on plastic, in a dose-dependent manner. In contrast, MCs in the collagen I gels showed no significant changes in mitogenicity or α1β1 and α5β1 integrin expression, but increased α1β1 integrin-mediated gel contraction was observed after PDGF-BB stimulation. Thus, the parallel up-regulation of MC-mitogenicity and α5β1 integrin expression by PDGF-BB suggested that α5β1 integrin is an important ECM receptor involved in the proliferative phenotype of MC. A spatial interaction between MCs and pathological collagen I in GN may influence the PDGF regulation of the MC phenotype regarding the cell growth and the expression of β1 integrins." @default.
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• W2024795009 date "1998-11-01" @default.
• W2024795009 modified "2023-10-05" @default.
• W2024795009 title "Collagen Type I Modulates the Platelet-Derived Growth Factor (PDGF) Regulation of the Growth and Expression of β1 Integrins by Rat Mesangial Cells" @default.
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• W2024795009 doi "https://doi.org/10.1006/bbrc.1998.9733" @default.
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