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- W2024795352 abstract "Mutations in myosin-VIIa are responsible for the deaf-blindness, Usher disease. Myosin-VIIa is also highly expressed in testis, where it is associated with specialized adhesion plaques termed ectoplasmic specializations (ES) that form between Sertoli cells and germ cells. To identify new roles for myosin-VIIa, we undertook a yeast two-hybrid screen to identify proteins associated with myosin-VIIa in the ES. We identified Keap1, a human homologue of the Drosophila ring canal protein, kelch. The kelch-repeats in the C-terminus of human Keap1 associate with the SH3 domain of myosin-VIIa. Immunolocalization studies revealed that Keap1 is present with myosin-VIIa in the actin bundles of the ES. Myosin-VIIa and Keap1 copurify with ES and colocate with each other and with F-actin at the electron microscopy level. Interestingly, in many epithelial cell types including cells derived from retina and inner ear, Keap1 is a component of focal adhesions and zipper junctions. Keap1 can target to the ES in the absence of myosin-VIIa, suggesting that Keap1 associates with other molecules in the adhesion plaque. Keap1 and myosin-VIIa overlapped in expression in the inner hair cells of the cochlea, suggesting that Keap1 may be a part of a family of actin-binding proteins that could be important for myosin-VIIa function in testis and inner ear." @default.
- W2024795352 created "2016-06-24" @default.
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- W2024795352 date "2002-03-01" @default.
- W2024795352 modified "2023-10-17" @default.
- W2024795352 title "A human homologue ofDrosophila kelch associates with myosin-VIIa in specialized adhesion junctions" @default.
- W2024795352 cites W1534393219 @default.
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- W2024795352 cites W1913862483 @default.
- W2024795352 cites W1964781666 @default.
- W2024795352 cites W1972136099 @default.
- W2024795352 cites W1977186059 @default.
- W2024795352 cites W1979642960 @default.
- W2024795352 cites W1984425391 @default.
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- W2024795352 cites W1990087177 @default.
- W2024795352 cites W1999967817 @default.
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- W2024795352 cites W2011745438 @default.
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- W2024795352 cites W2015903323 @default.
- W2024795352 cites W2023474594 @default.
- W2024795352 cites W2025139724 @default.
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- W2024795352 doi "https://doi.org/10.1002/cm.10025" @default.
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