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- W2024795849 endingPage "517" @default.
- W2024795849 startingPage "503" @default.
- W2024795849 abstract "Transforming growth factor-β (TGF-β) members are key cytokines that control embryogenesis and tissue homeostasis via transmembrane TGF-β type II (TβR II) and type I (TβRI) and serine/threonine kinases receptors. Aberrant activation of TGF-β signaling leads to diseases, including cancer. In advanced cancer, the TGF-β/SMAD pathway can act as an oncogenic factor driving tumor cell invasion and metastasis, and thus is considered to be a therapeutic target. The activity of TGF-β/SMAD pathway is known to be regulated by ubiquitination at multiple levels. As ubiquitination is reversible, emerging studies have uncovered key roles for ubiquitin-removals on TGF-β signaling components by deubiquitinating enzymes (DUBs). In this paper, we summarize the latest findings on the DUBs that control the activity of the TGF-β signaling pathway. The regulatory roles of these DUBs as a driving force for cancer progression as well as their underlying working mechanisms are also discussed." @default.
- W2024795849 created "2016-06-24" @default.
- W2024795849 creator A5015796005 @default.
- W2024795849 creator A5028710085 @default.
- W2024795849 creator A5045703368 @default.
- W2024795849 creator A5064167555 @default.
- W2024795849 creator A5067115806 @default.
- W2024795849 creator A5077552289 @default.
- W2024795849 creator A5080609124 @default.
- W2024795849 date "2014-04-23" @default.
- W2024795849 modified "2023-10-11" @default.
- W2024795849 title "The regulation of TGF-β/SMAD signaling by protein deubiquitination" @default.
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