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- W2024797603 abstract "Breakthrough after varicella vaccination occurs in approximately 2.6%∼18.6% of immunocompetent children, but the reason has not been demonstrated clearly. As a first defense, specific secretory IgA antibody on the mucosa plays an important role in preventing invasion of microorganisms. To examine induction of varicella-zoster virus (VZV) specific secretory IgA after natural infection and vaccination and its booster mechanisms, 143 salivary samples were tested by ELISA. The VZV-secretory IgA values were significantly higher in the matched children after natural chickenpox than in those after vaccination, although the total secretory IgA did not differ between them. Two (7%) of the vaccinees lacked the sIgA antibody. In the elderly and in immunocompromised children, the VZV-secretory IgA values were no lower than those in healthy children, and they did not lack VZV-secretory IgA. The doctors and nurses taking care of patients with chickenpox had higher values than the other groups as did individuals who had had herpes zoster recently. VZV-secretory IgA was thought to be stimulated by exogenous and reactivated endogenous VZV to neutralize VZV with weak activity. These results suggest that low or no induction of VZV-secretory IgA antibody after vaccination may be one of the possible explanations for a breakthrough. J. Med. Virol. 62:46–51, 2000. © 2000 Wiley-Liss, Inc." @default.
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- W2024797603 date "2000-01-01" @default.
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- W2024797603 title "Low induction of varicella-zoster virus-specific secretory IgA antibody after vaccination" @default.
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- W2024797603 doi "https://doi.org/10.1002/1096-9071(200009)62:1<46::aid-jmv8>3.0.co;2-y" @default.
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