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• W2024798765 abstract "The stems of Clerodendron trichotomum have been traditionally used for treatment of hypertension in far East Asia including China, Korea, and Japan. Bioassay-guided fractionation and purification of the EtOAc-soluble extract of Clerodendron trichotomum afforded acteoside (1), leucosceptoside A (2), martynoside (3), acteoside isomer (4), and isomartynoside (5). The angiotensin converting enzyme (ACE) activities were significantly inhibited by the addition of these phenylpropanoid glycosides (1-5) in a dose-dependent manner of which IC(50) values were 373+/-9.3 microg/ml, 423+/-18.8 microg/ml, 524+/-28.1 microg/ml, 376+/-15.6 microg/ml, 505+/-26.7 microg/ml, respectively. These results suggest that the antihypertensive effect of Clerodendron trichotomum may be, at least in part, due to ACE inhibitory effect of phenylpropanoid glycosides." @default.
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• W2024798765 date "2003-11-01" @default.
• W2024798765 modified "2023-10-16" @default.
• W2024798765 title "Angiotensin converting enzyme inhibitory phenylpropanoid glycosides from Clerodendron trichotomum" @default.
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• W2024798765 doi "https://doi.org/10.1016/s0378-8741(03)00274-5" @default.
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