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- W2024800940 abstract "The mechanisms of steroid action remain a poorly understood enigma. Although much effort has focused on the steroid receptor as a mediator of the steroid's effect in the cell, we are only beginning to understand the structure of steroid receptors. Development of monoclonal antibodies directed against both the steroid-binding receptors and receptor-associated proteins has allowed novel approaches to the problem. They were important in determining the nucleotide sequences of several receptor genes and subsequently the amino acid sequence of three receptors. Surprisingly, receptors contain amino acid sequences common to v-erb-A, a potentiator of oncogenic transformation. Two receptor-associated proteins have been found and their relationship to the receptors suggests the possibility of additional functions of receptors in addition to binding deoxyribonucleic acid. Thus the role of the receptor in the mechanism of steroid action is evolving from the two-step mechanism to one that includes the recently discovered receptor-associated proteins." @default.
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- W2024800940 date "1987-06-01" @default.
- W2024800940 modified "2023-09-25" @default.
- W2024800940 title "Evolving concepts in the mechanism of steroid action: Current developments" @default.
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- W2024800940 doi "https://doi.org/10.1016/0002-9378(87)90015-9" @default.
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