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- W2024804080 abstract "Fish oil reduces sudden cardiac death in post myocardial infarction patients. Life-threatening arrhythmias in heart failure are associated with repolarization abnormalities leading to EAD1 formation. We examined the effects of incorporated fish oil ω3-PUFAs2 on EAD formation in pig myocytes. Pigs were fed a diet rich in fish oil or sunflower oil (control) for 8 weeks. Myocytes were isolated by enzymatic dissociation and patch-clamped. Susceptibility to EAD formation was tested using E4031 (5 μM), a blocker of IKr. The fish oil diet in pigs resulted in increased incorporation of ω3-PUFAs in the sarcolemma of the myocytes compared to the control diet and caused a reduced occurrence of E4031-induced EADs in pig myocytes. A shorter action potential, a reduced action potential prolongation in response to E-4031 and a reduced reactivation of ICa,L by ω3-PUFAs may explain the observed reduction in EADs. A diet rich in fish oil protects against EAD formation." @default.
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- W2024804080 date "2006-11-01" @default.
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- W2024804080 title "Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes" @default.
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- W2024804080 doi "https://doi.org/10.1016/j.yjmcc.2006.08.001" @default.
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