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- W2024805483 endingPage "123" @default.
- W2024805483 startingPage "109" @default.
- W2024805483 abstract "It is estimated that 10 000 people per year die following trauma in England and Wales and 30—40% do so due to uncontrolled haemorrhage. By the time the patient reaches hospital, coagulopathy is often already installed and needs to be corrected promptly to prevent further haemorrhage and allow effective treatment of injuries. The coagulopathy is multifactorial with the leading causes being acidosis, hypothermia and massive transfusion. Early recognition of the condition is imperative using standard coagulation testing; however, there are limitations in this setting. Newer methods of testing `global haemostasis' using thromboelastography are becoming more popular but need further validation. Treatment of coagulopathy requires a multidisciplinary approach. Blood product transfusion remains the cornerstone of management but newer pharmacological agents such as recombinant factor VIIa are increasingly being used. Here we review the pathogenesis, investigation and management of the coagulopathy of trauma." @default.
- W2024805483 created "2016-06-24" @default.
- W2024805483 creator A5070399571 @default.
- W2024805483 creator A5084093565 @default.
- W2024805483 date "2008-04-01" @default.
- W2024805483 modified "2023-09-23" @default.
- W2024805483 title "Coagulopathy in trauma: optimising haematological status" @default.
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