Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024806087> ?p ?o ?g. }
- W2024806087 endingPage "168" @default.
- W2024806087 startingPage "157" @default.
- W2024806087 abstract "In seven methadone-maintained human participants trained to distinguish between a low dose of naloxone (0.15 mg/70 kg, i.m.; i.e., Drug A) and placebo (i.e., Drug B) under an instructed novel-response drug discrimination procedure, the calcium channel blocker isradipine (0-10 mg/70 kg, p.o.; N=7) and the N-methyl-D-aspartic acid (NMDA) receptor antagonist dextromethorphan (0-60 mg/70 kg, p.o.; N=6) were tested each alone and in combination with the training dose of naloxone. Isradipine alone produced some naloxone- and novel-appropriate responding, minimal changes in self-reports and decreases in blood pressure. Dextromethorphan alone produced some novel-appropriate responding and minimal changes in self-reports and vital signs. When combined with naloxone, isradipine significantly attenuated naloxone-occasioned responding, without increasing novel-appropriate responding, and attenuated naloxone-induced increases in opioid receptor antagonist ratings and ratings measuring sedation. Dextromethorphan significantly attenuated naloxone-appropriate responding, increased novel-appropriate responding, and enhanced naloxone's effects on ratings of dysphoric effects. These results suggest that isradipine attenuates and dextromethorphan enhances some of the behavioral effects of naloxone in opioid-dependent humans." @default.
- W2024806087 created "2016-06-24" @default.
- W2024806087 creator A5044842506 @default.
- W2024806087 creator A5054472146 @default.
- W2024806087 creator A5071214414 @default.
- W2024806087 creator A5087683644 @default.
- W2024806087 date "2004-05-01" @default.
- W2024806087 modified "2023-10-17" @default.
- W2024806087 title "Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure" @default.
- W2024806087 cites W1785119030 @default.
- W2024806087 cites W1964295968 @default.
- W2024806087 cites W1971006312 @default.
- W2024806087 cites W1974574229 @default.
- W2024806087 cites W1977492939 @default.
- W2024806087 cites W1977980861 @default.
- W2024806087 cites W1980356075 @default.
- W2024806087 cites W1982666112 @default.
- W2024806087 cites W1983167472 @default.
- W2024806087 cites W1984269937 @default.
- W2024806087 cites W1995638617 @default.
- W2024806087 cites W1997912746 @default.
- W2024806087 cites W1998161231 @default.
- W2024806087 cites W2001263497 @default.
- W2024806087 cites W2005367471 @default.
- W2024806087 cites W2010757197 @default.
- W2024806087 cites W2011038828 @default.
- W2024806087 cites W2012659957 @default.
- W2024806087 cites W2016018088 @default.
- W2024806087 cites W2019623109 @default.
- W2024806087 cites W2020727086 @default.
- W2024806087 cites W2026177463 @default.
- W2024806087 cites W2026746764 @default.
- W2024806087 cites W2029690925 @default.
- W2024806087 cites W2033525233 @default.
- W2024806087 cites W2034348223 @default.
- W2024806087 cites W2044992755 @default.
- W2024806087 cites W2049149575 @default.
- W2024806087 cites W2050347703 @default.
- W2024806087 cites W2063073133 @default.
- W2024806087 cites W2064592371 @default.
- W2024806087 cites W2068759117 @default.
- W2024806087 cites W2069696287 @default.
- W2024806087 cites W2069841413 @default.
- W2024806087 cites W2070146447 @default.
- W2024806087 cites W2072890498 @default.
- W2024806087 cites W2084663429 @default.
- W2024806087 cites W2088054863 @default.
- W2024806087 cites W2095126144 @default.
- W2024806087 cites W2095555020 @default.
- W2024806087 cites W2096729002 @default.
- W2024806087 cites W2104568075 @default.
- W2024806087 cites W2106528529 @default.
- W2024806087 cites W2115725157 @default.
- W2024806087 cites W2138195260 @default.
- W2024806087 cites W2138928757 @default.
- W2024806087 cites W2143429166 @default.
- W2024806087 cites W2155053260 @default.
- W2024806087 cites W2159439931 @default.
- W2024806087 cites W2167195669 @default.
- W2024806087 cites W2169992401 @default.
- W2024806087 cites W2172018409 @default.
- W2024806087 cites W2328820758 @default.
- W2024806087 cites W4251743550 @default.
- W2024806087 cites W4253992600 @default.
- W2024806087 cites W4319688303 @default.
- W2024806087 cites W54728729 @default.
- W2024806087 doi "https://doi.org/10.1016/j.ejphar.2004.03.024" @default.
- W2024806087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15140632" @default.
- W2024806087 hasPublicationYear "2004" @default.
- W2024806087 type Work @default.
- W2024806087 sameAs 2024806087 @default.
- W2024806087 citedByCount "9" @default.
- W2024806087 countsByYear W20248060872013 @default.
- W2024806087 countsByYear W20248060872020 @default.
- W2024806087 countsByYear W20248060872021 @default.
- W2024806087 countsByYear W20248060872022 @default.
- W2024806087 countsByYear W20248060872023 @default.
- W2024806087 crossrefType "journal-article" @default.
- W2024806087 hasAuthorship W2024806087A5044842506 @default.
- W2024806087 hasAuthorship W2024806087A5054472146 @default.
- W2024806087 hasAuthorship W2024806087A5071214414 @default.
- W2024806087 hasAuthorship W2024806087A5087683644 @default.
- W2024806087 hasConcept C126322002 @default.
- W2024806087 hasConcept C170493617 @default.
- W2024806087 hasConcept C185592680 @default.
- W2024806087 hasConcept C2776066529 @default.
- W2024806087 hasConcept C2776885963 @default.
- W2024806087 hasConcept C2777389121 @default.
- W2024806087 hasConcept C2778750930 @default.
- W2024806087 hasConcept C2778767360 @default.
- W2024806087 hasConcept C2779591118 @default.
- W2024806087 hasConcept C2781063702 @default.
- W2024806087 hasConcept C2781245242 @default.
- W2024806087 hasConcept C3019590667 @default.
- W2024806087 hasConcept C42219234 @default.
- W2024806087 hasConcept C71924100 @default.
- W2024806087 hasConcept C98274493 @default.
- W2024806087 hasConceptScore W2024806087C126322002 @default.