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• W2024807557 abstract "A series of 3-polyaminochenodeoxycholic acid derivatives were synthesized and their in vitro antimicrobial and antifungal activities were assessed. The antimicrobial activity was evaluated against Gram-positive and Gram-negative bacteria, and the antifungal activity was assessed against two strains Candida albicans (ATCC MYA-1003) and Aspergillus fumigatus (ATCC 16424). The introduction of an amine group to steroid was accomplished by reductive amination of 3-oxosteroid 9 with Boc-spermidine and Boc-spermine, in the presence of NaBH(OAc)3. This afforded a high yield of 3-polyaminosteroids of 10–13. The 3β-sperminyl-5β-cholane 6 showed the highest antimicrobial activity against Streptococcus pyogenes 308A, Staphylococcus aureus 503, Escherichia coli DC2 and Pseudomonas aeruginosa 9027 with a MIC value of 3.13 μg/mL." @default.
• W2024807557 created "2016-06-24" @default.
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• W2024807557 date "2009-07-01" @default.
• W2024807557 modified "2023-09-27" @default.
• W2024807557 title "Synthesis and biological activities of 3-polyamino-5β-cholane-7α,24-diols" @default.
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• W2024807557 doi "https://doi.org/10.1016/j.jiec.2009.01.013" @default.
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