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- W2024808749 abstract "<h3>To the Editor.—</h3> In reference to the recent letters of Donald B. Douglas, MD (227:439, 1974), and Peter J. Jannetta, MD (228:1637, 1974), we would like to present a theoretical explanation for the selective susceptibility of large-diameter axons to pressure-induced neuropathies.<sup>1-3</sup>Although this is not a new observation, the theoretical explanation has been lacking. We suggest that this is due to Laplace's Law<sup>4</sup>that states that in the special situation of a thin-walled cylinder (like an axon), T=P×R where T is the tension (stress or force per unit area) in the wall of the cylinder parallel to a circumference; P, the transmural pressure; and R, the radius of the cylinder. For example, consider two cylinders whose transmural pressures are identical but whose radii differ: the larger cylinder will have more tension (stress) in its wall. If this stress is too great, the cylinder's wall, in our case an" @default.
- W2024808749 created "2016-06-24" @default.
- W2024808749 creator A5047602511 @default.
- W2024808749 date "1974-09-30" @default.
- W2024808749 modified "2023-10-10" @default.
- W2024808749 title "Laplace's Law, Pressure Neuropathy, Tabes Dorsalis, Tic Douloureux, Facial Spasm" @default.
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- W2024808749 doi "https://doi.org/10.1001/jama.1974.03230520012008" @default.
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- W2024808749 hasPublicationYear "1974" @default.
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