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• W2024811220 abstract "Ten p-nitrodiarylthiourea analogs were designed, synthesized and evaluated in breast (MCF-7, T-47D, MDA-MB-453) and prostate (DU-145, PC-3, LNCaP) cancer cell lines for their anticancer activities. The majority of the compounds were able to inhibit the growth of these six cancer cell lines at low micromolar concentrations. Compound 7 was found to be the most potent anticancer agent in this series with GI50 values of 3.16 μM for MCF-7, 2.53 μM for T-47D, 4.77 μM for MDA-MB-453 breast cancer lines and 3.54 μM for LNCaP prostate cancer cell line. These GI50 values were comparable to the parent compound, SHetA2." @default.
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• W2024811220 date "2015-03-01" @default.
• W2024811220 modified "2023-10-18" @default.
• W2024811220 title "Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents" @default.
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• W2024811220 doi "https://doi.org/10.1016/j.bmcl.2015.01.042" @default.
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