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- W2024815061 abstract "Multiple sclerosis, an inflammatory disease of the central nervous system, is characterized by primary destruction of myelin. This review covers recent advances in neuropathology, immunogenetics, neuroimmunology, and neurovirology that have provided insights regarding its pathogenesis. Three hypotheses are discussed: (1) autoimmunity, (2) bystander demyelination, and (3) immune destruction of persistently infected oligodendrocytes. A paradigm for induction of primary demyelination is proposed in which immune cells recognize foreign antigens on the surface of oligodendrocytes in the context of major histocompatibility complex gene products. The final result of this scheme may be dying-back gliopathy, the alteration being noted first in the most distal extension of the oligodendrocyte--that is, the myelin sheaths." @default.
- W2024815061 created "2016-06-24" @default.
- W2024815061 creator A5052262813 @default.
- W2024815061 date "1989-05-01" @default.
- W2024815061 modified "2023-09-27" @default.
- W2024815061 title "Multiple Sclerosis: Basic Concepts and Hypothesis" @default.
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- W2024815061 doi "https://doi.org/10.1016/s0025-6196(12)65563-3" @default.
- W2024815061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7095196" @default.
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