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• W2024822571 startingPage "98" @default.
• W2024822571 abstract "Carcinoma tumor cells express highly glycosylated mucins acting as ligands for selectin adhesion receptors and thus facilitating the metastatic process. Recently, a sulfated galactocerebroside SM4 was detected as solely P-selectin ligand on MC-38 colon carcinoma cells. Here we characterize the functionality of SM4 as selectin ligand using model membrane approaches. SM4 was found concentrated in lipid rafts of MC-38 cells indicating a local clustering that may increase the avidity of P-selectin recognition. To confirm this, SM4 was incorporated at various concentrations into POPC model membranes and lateral clustering was analyzed by fluorescence microscopy and found to be comparable to glycolipids carrying the sLex epitope. SM4 containing liposomes were used as cell models, binding to immobilized P-selectin. Quartz crystal microbalance data confirmed SM4/P-selectin liposome binding that was inhibited dose-dependently by heparin. Comparable binding characteristics of SM4 and sLex liposomes underscore the similarity of these epitopes. Thus, clustering of SM4 on tumor cells is a principle for binding P-selectin." @default.
• W2024822571 created "2016-06-24" @default.
• W2024822571 creator A5022422907 @default.
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• W2024822571 creator A5044983858 @default.
• W2024822571 creator A5047132606 @default.
• W2024822571 creator A5052228601 @default.
• W2024822571 date "2010-08-01" @default.
• W2024822571 modified "2023-09-27" @default.
• W2024822571 title "Analysis of SM4 sulfatide as a P-selectin ligand using model membranes" @default.
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• W2024822571 doi "https://doi.org/10.1016/j.bpc.2010.01.007" @default.
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• W2024822571 hasPublicationYear "2010" @default.
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