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• W2024831942 endingPage "179" @default.
• W2024831942 startingPage "169" @default.
• W2024831942 abstract "Anti-Müllerian hormone (AMH) is a dimeric glycoprotein member of the TGF-β family. It is synthesized by immature Sertoli cells, and, to a lesser degree, by adult Sertoli and granulosa cells. AMH is responsible for the regression of Müllerian ducts in the male fetus; it also has deleterious effects on the female fetal reproductive tract, destroying Müllerian primordia and germ cells, and masculinizing the fetal ovary on the rare occasions female fetuses become exposed to its effects. All other suggested actions for AMH—retardation of oocyte meiosis, inhibition of EGF receptor autophosphorylation, anti-cancer activity—have been reported with crude hormone preparations, and have not been confirmed using pure AMH. Its relatively limited sphere of action—the fetal genital tract—and the fact that it is secreted into the general circulation and can act at long range, imply that AMH is more like a hormone than a growth factor, but the complex interaction between hormones and growth factors make a formal distinction impossible." @default.
• W2024831942 created "2016-06-24" @default.
• W2024831942 creator A5016664517 @default.
• W2024831942 date "1990-01-01" @default.
• W2024831942 modified "2023-09-25" @default.
• W2024831942 title "Anti-Müllerian hormone: Hormone or growth factor?" @default.
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• W2024831942 doi "https://doi.org/10.1016/0955-2235(90)90003-3" @default.
• W2024831942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2132954" @default.
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