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• W2024832063 abstract "ObjectivesIncreasing evidence has mounted in recent years on the potential prognostic role of biomarkers out of cardiac-specific medical settings. We aimed to test whether cardiac and inflammatory biomarkers are independently associated with in-hospital mortality in older unselected medical inpatients undergoing standardized multidimensional evaluation.DesignObservational study conducted in a metropolitan university-teaching hospital. A standardized, multidimensional analysis was carried out on all patients by using medical and hospital discharge documentation and interview results integrated with information collected from family members or caregivers.Participants and settingPatients older than 65 years consecutively admitted to the acute geriatric ward and to 2 acute medical wards of the hospital.ResultsMale sex; low systolic blood pressure; APACHE score; functional impairment in activities of daily living (ADLs), instrumental ADLs, and Short Physical Performance Battery (SPPB); cognitive impairment; malnutrition; low albumin values; and elevated values of inflammatory and cardiac biomarkers were significantly associated with in-hospital mortality at univariate analysis. After multivariate analysis, male sex, low systolic blood pressure values at entry, severe cognitive impairment, and low functional performance measured by the SPPB resulted to be independently associated with in-hospital mortality.ConclusionsThe main finding of the present study is that these biomarkers, although associated with in-hospital mortality, do not have independent predictive significance when a comprehensive and multidimensional evaluation is conducted. The main clinical implication is that our findings should discourage the indiscriminate recourse to measurement of cardiac and inflammatory biomarkers, at least in older medical inpatients, thereby reducing a patient's hospital cost and potentially minimizing further unnecessary diagnostic procedures." @default.
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• W2024832063 date "2014-01-01" @default.
• W2024832063 modified "2023-10-18" @default.
• W2024832063 title "Cardiac and Inflammatory Biomarkers and In-hospital Mortality in Older Medical Patients" @default.
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• W2024832063 doi "https://doi.org/10.1016/j.jamda.2013.10.013" @default.
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