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• W2024841411 abstract "The neuroprotective actions of the anticonvulsant phenytoin (diphenylhydantoin, PHT) were evaluated using 3 week old primary hippocampal cultures derived from 19 day embryonic rat. When added to the culture medium prior to a hypoxic insult, PHT increased neuronal viability two-fold. Doubling extracellular Mg2+ concentration was similarly neuroprotective. In contrast, PHT was unable to protect against hypoxia-induced death in one week old cultures, nor was PHT protective against N-methyl-D-aspartate (NMDA)-induced neurotoxicity in cultures of either age. These findings suggest that non-NMDA receptor mechanisms are important in hypoxia-induced neuronal death, and may have important implications for the treatment of stroke." @default.
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• W2024841411 date "1994-07-01" @default.
• W2024841411 modified "2023-09-26" @default.
• W2024841411 title "Phenytoin protects against hypoxia-induced death of cultured hippocampal neurons" @default.
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• W2024841411 doi "https://doi.org/10.1016/0304-3940(94)91106-1" @default.
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