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- W2024843655 endingPage "240" @default.
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- W2024843655 abstract "CD4(+)CD25(+/high)Foxp3(+) regulatory T (Treg) cells are a subset of CD4(+) T cells that play an essential role in maintaining peripheral immune tolerance. Several transcriptional cofactors have been recently identified, which form complexes with transcription factor Foxp3 of Treg cells and contribute in the suppressive function of Treg cells. However, Foxp3 is still defined as a master (multiple pathway) regulator gene that controls the development and stability of Treg cells. Because of its importance, the regulatory mechanisms underlying Foxp3 expression have been a focus of intensive investigation. Recent progress suggests that the epigenetic mechanisms responsible for regulating the Foxp3 gene expression are key components of suppressive activity of Treg cells. This review not only discusses the basic concepts of biology and epigenetic modifications of Treg cells, but also analyzes the translational clinical aspect of epigenetic modifications of Treg cells, focusing on several ongoing clinical trials and the Food and Drugs administration (FDA) approved epigenetic-based drugs. The new progress in identifying epigenetic enzymes functional in Treg cells is a new target for the development of novel therapeutic approaches for autoimmune and inflammatory diseases, graft-vs-host disease and cancers." @default.
- W2024843655 created "2016-06-24" @default.
- W2024843655 creator A5025334761 @default.
- W2024843655 creator A5047172495 @default.
- W2024843655 creator A5069971376 @default.
- W2024843655 creator A5079855188 @default.
- W2024843655 creator A5082502067 @default.
- W2024843655 date "2015-01-01" @default.
- W2024843655 modified "2023-10-01" @default.
- W2024843655 title "Epigenetic enzymes are the therapeutic targets for CD4+CD25+/highFoxp3+ regulatory T cells" @default.
- W2024843655 cites W1486722793 @default.
- W2024843655 cites W1533191645 @default.
- W2024843655 cites W1559702560 @default.
- W2024843655 cites W1575585006 @default.
- W2024843655 cites W1666105976 @default.
- W2024843655 cites W1674079630 @default.
- W2024843655 cites W1676106065 @default.
- W2024843655 cites W1964767882 @default.
- W2024843655 cites W1967007963 @default.
- W2024843655 cites W1967160536 @default.
- W2024843655 cites W1967355315 @default.
- W2024843655 cites W1968597118 @default.
- W2024843655 cites W1971969082 @default.
- W2024843655 cites W1972421380 @default.
- W2024843655 cites W1973750557 @default.
- W2024843655 cites W1974863119 @default.
- W2024843655 cites W1975054545 @default.
- W2024843655 cites W1977836556 @default.
- W2024843655 cites W1980448977 @default.
- W2024843655 cites W1981861721 @default.
- W2024843655 cites W1982417006 @default.
- W2024843655 cites W1983019708 @default.
- W2024843655 cites W1985406652 @default.
- W2024843655 cites W1985444222 @default.
- W2024843655 cites W1987095957 @default.
- W2024843655 cites W1989354231 @default.
- W2024843655 cites W1989722258 @default.
- W2024843655 cites W1992375755 @default.
- W2024843655 cites W1992618238 @default.
- W2024843655 cites W1992641327 @default.
- W2024843655 cites W1992979605 @default.
- W2024843655 cites W1996676239 @default.
- W2024843655 cites W1998517881 @default.
- W2024843655 cites W2000090224 @default.
- W2024843655 cites W2002698073 @default.
- W2024843655 cites W2002726823 @default.
- W2024843655 cites W2003617318 @default.
- W2024843655 cites W2005451808 @default.
- W2024843655 cites W2005471059 @default.
- W2024843655 cites W2006193946 @default.
- W2024843655 cites W2007150296 @default.
- W2024843655 cites W2007711648 @default.
- W2024843655 cites W2007955797 @default.
- W2024843655 cites W2008859070 @default.
- W2024843655 cites W2010291571 @default.
- W2024843655 cites W2012589963 @default.
- W2024843655 cites W2013010265 @default.
- W2024843655 cites W2014260710 @default.
- W2024843655 cites W2014869583 @default.
- W2024843655 cites W2015587858 @default.
- W2024843655 cites W2015991580 @default.
- W2024843655 cites W2016910859 @default.
- W2024843655 cites W2017104717 @default.
- W2024843655 cites W2018050275 @default.
- W2024843655 cites W2018403469 @default.
- W2024843655 cites W2019080597 @default.
- W2024843655 cites W2019918813 @default.
- W2024843655 cites W2019928804 @default.
- W2024843655 cites W2022837368 @default.
- W2024843655 cites W2022920759 @default.
- W2024843655 cites W2022936129 @default.
- W2024843655 cites W2023513332 @default.
- W2024843655 cites W2023653642 @default.
- W2024843655 cites W2025633611 @default.
- W2024843655 cites W2026635725 @default.
- W2024843655 cites W2027198537 @default.
- W2024843655 cites W2028304885 @default.
- W2024843655 cites W2029903254 @default.
- W2024843655 cites W2030637684 @default.
- W2024843655 cites W2030972824 @default.
- W2024843655 cites W2032917789 @default.
- W2024843655 cites W2036828137 @default.
- W2024843655 cites W2039513919 @default.
- W2024843655 cites W2041079472 @default.
- W2024843655 cites W2045450732 @default.
- W2024843655 cites W2048181263 @default.
- W2024843655 cites W2048729217 @default.
- W2024843655 cites W2049195493 @default.
- W2024843655 cites W2049764386 @default.
- W2024843655 cites W2050093027 @default.
- W2024843655 cites W2051544310 @default.
- W2024843655 cites W2052522631 @default.
- W2024843655 cites W2053351225 @default.
- W2024843655 cites W2053796439 @default.
- W2024843655 cites W2054344840 @default.
- W2024843655 cites W2056138805 @default.
- W2024843655 cites W2057199826 @default.
- W2024843655 cites W2059283750 @default.