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- W2024844089 abstract "In this article, a framework for an in silico pipeline is presented as a guide to high-throughput vaccine candidate discovery for eukaryotic pathogens, such as helminths and protozoa. Eukaryotic pathogens are mostly parasitic and cause some of the most damaging and difficult to treat diseases in humans and livestock. Consequently, these parasitic pathogens have a significant impact on economy and human health. The pipeline is based on the principle of reverse vaccinology and is constructed from freely available bioinformatics programs. There are several successful applications of reverse vaccinology to the discovery of subunit vaccines against prokaryotic pathogens but not yet against eukaryotic pathogens. The overriding aim of the pipeline, which focuses on eukaryotic pathogens, is to generate through computational processes of elimination and evidence gathering a ranked list of proteins based on a scoring system. These proteins are either surface components of the target pathogen or are secreted by the pathogen and are of a type known to be antigenic. No perfect predictive method is yet available; therefore, the highest-scoring proteins from the list require laboratory validation." @default.
- W2024844089 created "2016-06-24" @default.
- W2024844089 creator A5007566988 @default.
- W2024844089 creator A5045984899 @default.
- W2024844089 creator A5080194823 @default.
- W2024844089 date "2012-10-24" @default.
- W2024844089 modified "2023-10-05" @default.
- W2024844089 title "A guide to in silico vaccine discovery for eukaryotic pathogens" @default.
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