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• W2024846413 abstract "We have previously reported that murine peritoneal macrophages exposed to ultraviolet B (UV-B; 100 mJ/cm2) undergo apoptosis, as indicated by alterations in cell morphology, caspase-3 activation, poly (ADP-ribose) polymerase (PARP) cleavage, DNA fragmentation, sustained activation of p38/c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) and inactivation of p42/44 MAPKs. It is now reported that macrophages undergoing UV-B-induced apoptosis show enhanced expression of protein kinase Cδ (PKCδ) in a time-dependent manner. Pretreatment of macrophages with PKCδ-specific inhibitor rottlerin prior to the UV-B irradiation inhibits activation of caspase-3, PARP cleavage, DNA fragmentation and release of intracellular Ca2+. Inhibition of PKCδ also blocks the sustained activation of p38 and JNK MAPKs as well as inactivation of p42/44 MAPKs. PKCα and PKCβ1 expression also increases during UV-B-induced apoptosis in macrophages. Inhibition of these two isoforms with Go6976 slightly suppresses caspase-3 activation, PARP cleavage, DNA fragmentation and release of intracellular Ca2+, but has no effect on the sustained activation of p38/JNK MAPKs or inactivation of p42/44 MAPKs. It is, therefore, suggested that activation of PKCδ might play an important role in the UV-B-induced apoptosis and that specific activated isoforms of PKC may have distinct functions in cell death." @default.
• W2024846413 created "2016-06-24" @default.
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• W2024846413 date "2005-03-01" @default.
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• W2024846413 title "Role of protein kinase Cδ in UV-B-induced apoptosis of macrophages in vitro" @default.
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• W2024846413 doi "https://doi.org/10.1016/j.cellsig.2004.08.004" @default.
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