Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024846557> ?p ?o ?g. }
- W2024846557 endingPage "2408" @default.
- W2024846557 startingPage "2397" @default.
- W2024846557 abstract "The T-box gene Eomesodermin (Eomes) is required for early embryonic mesoderm differentiation in mouse, frog (Xenopus laevis), and zebrafish, is important in late cardiac development in Xenopus, and for CD8+ T effector cell function in mouse. Eomes can ectopically activate many mesodermal genes. However, the mechanism by which Eomes activates transcription of these genes is poorly understood. We report that Eomes protein interacts with Smad2 and is capable of working in a non-cell autonomous manner via transfer of Eomes protein between adjacent embryonic cells. Blocking of Eomes protein transfer using a farnesylated red fluorescent protein (CherryF) also prevents Eomes nuclear accumulation. Transfer of Eomes protein between cells is mediated by the Eomes carboxyl terminus (456-692). A carbohydrate binding domain within the Eomes carboxyl-terminal region is sufficient for transfer and important for gene activation. We propose a novel mechanism by which Eomes helps effect a cellular response to a morphogen gradient." @default.
- W2024846557 created "2016-06-24" @default.
- W2024846557 creator A5019796960 @default.
- W2024846557 creator A5028905265 @default.
- W2024846557 creator A5047596852 @default.
- W2024846557 creator A5072920942 @default.
- W2024846557 date "2009-01-01" @default.
- W2024846557 modified "2023-09-26" @default.
- W2024846557 title "Eomesodermin Requires Transforming Growth Factor-β/Activin Signaling and Binds Smad2 to Activate Mesodermal Genes" @default.
- W2024846557 cites W1518787232 @default.
- W2024846557 cites W1589678790 @default.
- W2024846557 cites W1963780732 @default.
- W2024846557 cites W1967088584 @default.
- W2024846557 cites W1974186613 @default.
- W2024846557 cites W1976785514 @default.
- W2024846557 cites W1982535880 @default.
- W2024846557 cites W1994144105 @default.
- W2024846557 cites W1995644262 @default.
- W2024846557 cites W1999409126 @default.
- W2024846557 cites W2004283021 @default.
- W2024846557 cites W2004908889 @default.
- W2024846557 cites W2012945589 @default.
- W2024846557 cites W2014245863 @default.
- W2024846557 cites W2026065678 @default.
- W2024846557 cites W2040499298 @default.
- W2024846557 cites W2041094853 @default.
- W2024846557 cites W2046194583 @default.
- W2024846557 cites W2046256742 @default.
- W2024846557 cites W2046892081 @default.
- W2024846557 cites W2052598541 @default.
- W2024846557 cites W2057581247 @default.
- W2024846557 cites W2062625771 @default.
- W2024846557 cites W2073027322 @default.
- W2024846557 cites W2074629755 @default.
- W2024846557 cites W2080546144 @default.
- W2024846557 cites W2083032412 @default.
- W2024846557 cites W2089367238 @default.
- W2024846557 cites W2094002913 @default.
- W2024846557 cites W2095605427 @default.
- W2024846557 cites W2098301486 @default.
- W2024846557 cites W2103195240 @default.
- W2024846557 cites W2110632663 @default.
- W2024846557 cites W2119319172 @default.
- W2024846557 cites W2132059662 @default.
- W2024846557 cites W2132069716 @default.
- W2024846557 cites W2132669667 @default.
- W2024846557 cites W2144634347 @default.
- W2024846557 cites W2150947848 @default.
- W2024846557 cites W2158714788 @default.
- W2024846557 cites W55460750 @default.
- W2024846557 cites W87643743 @default.
- W2024846557 doi "https://doi.org/10.1074/jbc.m808704200" @default.
- W2024846557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2629102" @default.
- W2024846557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19036723" @default.
- W2024846557 hasPublicationYear "2009" @default.
- W2024846557 type Work @default.
- W2024846557 sameAs 2024846557 @default.
- W2024846557 citedByCount "18" @default.
- W2024846557 countsByYear W20248465572012 @default.
- W2024846557 countsByYear W20248465572013 @default.
- W2024846557 countsByYear W20248465572014 @default.
- W2024846557 countsByYear W20248465572015 @default.
- W2024846557 countsByYear W20248465572016 @default.
- W2024846557 countsByYear W20248465572017 @default.
- W2024846557 countsByYear W20248465572020 @default.
- W2024846557 countsByYear W20248465572022 @default.
- W2024846557 crossrefType "journal-article" @default.
- W2024846557 hasAuthorship W2024846557A5019796960 @default.
- W2024846557 hasAuthorship W2024846557A5028905265 @default.
- W2024846557 hasAuthorship W2024846557A5047596852 @default.
- W2024846557 hasAuthorship W2024846557A5072920942 @default.
- W2024846557 hasBestOaLocation W20248465571 @default.
- W2024846557 hasConcept C104317684 @default.
- W2024846557 hasConcept C145103041 @default.
- W2024846557 hasConcept C2776878037 @default.
- W2024846557 hasConcept C2778386714 @default.
- W2024846557 hasConcept C2779535977 @default.
- W2024846557 hasConcept C2780915607 @default.
- W2024846557 hasConcept C51785407 @default.
- W2024846557 hasConcept C54355233 @default.
- W2024846557 hasConcept C86339819 @default.
- W2024846557 hasConcept C86803240 @default.
- W2024846557 hasConcept C95444343 @default.
- W2024846557 hasConceptScore W2024846557C104317684 @default.
- W2024846557 hasConceptScore W2024846557C145103041 @default.
- W2024846557 hasConceptScore W2024846557C2776878037 @default.
- W2024846557 hasConceptScore W2024846557C2778386714 @default.
- W2024846557 hasConceptScore W2024846557C2779535977 @default.
- W2024846557 hasConceptScore W2024846557C2780915607 @default.
- W2024846557 hasConceptScore W2024846557C51785407 @default.
- W2024846557 hasConceptScore W2024846557C54355233 @default.
- W2024846557 hasConceptScore W2024846557C86339819 @default.
- W2024846557 hasConceptScore W2024846557C86803240 @default.
- W2024846557 hasConceptScore W2024846557C95444343 @default.
- W2024846557 hasIssue "4" @default.
- W2024846557 hasLocation W20248465571 @default.
- W2024846557 hasLocation W20248465572 @default.
- W2024846557 hasLocation W20248465573 @default.