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- W2024848032 abstract "Impairment of penicillin G excretion in renal failure may result in life-threatening, dose-related toxicity. We report a method for achieving a desired mean serum penicillin G concentration in patients with renal failure, with minimal risk of both undertreatment and drug toxicity. The method is based on the linear relation between the total plasma clearance of penicillin G (Cpen) and the endogenous creatinine clearance. The daily maintenance dose of penicillin G (units) is defined by the product, Cpen (ml/min) X desired mean serum penicillin G concentration (µg/ml) X 2300. Application of this method to patients with various degrees of renal impairment by either constant-rate infusion or intermittent infusion gave serum penicillin G concentrations within the desired range in all but 1 of 15 instances. On the basis of these observations, practical guidelines for comparably massive penicillin G therapy are suggested." @default.
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- W2024848032 date "1975-02-01" @default.
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- W2024848032 title "Comparably Massive Penicillin G Therapy in Renal Failure" @default.
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- W2024848032 doi "https://doi.org/10.7326/0003-4819-82-2-189" @default.
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