FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024852782> ?p ?o ?g. }

• W2024852782 abstract "Telomeres are essential for chromosome stability and the regulation of the replicative life-span of somatic cells. Many studies showed that exogenous telomeric repeats could activate p53 protein. It is not known how cell dysfunction is induced by telomeric plasmids. A covalent closed circular (ccc) double-stranded plasmid containing (TTAGGG)(96) repeats (pRST5) was transiently transfected into the human gastric cancer MGC-803 cells. We first confirmed that the cell viabilities decreased by 27%, cell senescence increased by 62% and G2/M cycle arrested in pRST5 plasmid transfected cells. Compared to control groups, cells transfected with telomeric plasmids showed an ATM-dependent increasing of p53, TRF1, and TRF2 expression. Furthermore, telomere dysfunction-induced foci (TIF) were observed. In conclusion, telomeric plasmids can elicit endogenous telomere dysfunction and induce cell senescence by activating ATM-p53 pathway." @default.
• W2024852782 created "2016-06-24" @default.
• W2024852782 creator A5038244626 @default.
• W2024852782 creator A5091688912 @default.
• W2024852782 date "2010-06-10" @default.
• W2024852782 modified "2023-09-28" @default.
• W2024852782 title "Telomeric plasmid induces human cancer cell dysfunction depending on ATM activity" @default.
• W2024852782 cites W1963699429 @default.
• W2024852782 cites W1966288363 @default.
• W2024852782 cites W1969863269 @default.
• W2024852782 cites W1972655555 @default.
• W2024852782 cites W1979609161 @default.
• W2024852782 cites W1989635874 @default.
• W2024852782 cites W2000316470 @default.
• W2024852782 cites W2017606844 @default.
• W2024852782 cites W2022811243 @default.
• W2024852782 cites W2032407757 @default.
• W2024852782 cites W2033731825 @default.
• W2024852782 cites W2035389897 @default.
• W2024852782 cites W2038934448 @default.
• W2024852782 cites W2042377388 @default.
• W2024852782 cites W2049448938 @default.
• W2024852782 cites W2050674095 @default.
• W2024852782 cites W2055580680 @default.
• W2024852782 cites W2055658305 @default.
• W2024852782 cites W2078465024 @default.
• W2024852782 cites W2085907623 @default.
• W2024852782 cites W2086992094 @default.
• W2024852782 cites W2087017789 @default.
• W2024852782 cites W2122733437 @default.
• W2024852782 cites W2123105653 @default.
• W2024852782 cites W2123126056 @default.
• W2024852782 cites W2142544392 @default.
• W2024852782 cites W2160185049 @default.
• W2024852782 doi "https://doi.org/10.1002/cbf.1664" @default.
• W2024852782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20535839" @default.
• W2024852782 hasPublicationYear "2010" @default.
• W2024852782 type Work @default.
• W2024852782 sameAs 2024852782 @default.
• W2024852782 citedByCount "2" @default.
• W2024852782 countsByYear W20248527822012 @default.
• W2024852782 countsByYear W20248527822018 @default.
• W2024852782 crossrefType "journal-article" @default.
• W2024852782 hasAuthorship W2024852782A5038244626 @default.
• W2024852782 hasAuthorship W2024852782A5091688912 @default.
• W2024852782 hasConcept C104317684 @default.
• W2024852782 hasConcept C134305767 @default.
• W2024852782 hasConcept C1491633281 @default.
• W2024852782 hasConcept C153911025 @default.
• W2024852782 hasConcept C16613235 @default.
• W2024852782 hasConcept C171350616 @default.
• W2024852782 hasConcept C177336024 @default.
• W2024852782 hasConcept C22744801 @default.
• W2024852782 hasConcept C25602115 @default.
• W2024852782 hasConcept C522857546 @default.
• W2024852782 hasConcept C54009773 @default.
• W2024852782 hasConcept C54355233 @default.
• W2024852782 hasConcept C552990157 @default.
• W2024852782 hasConcept C55493867 @default.
• W2024852782 hasConcept C62112901 @default.
• W2024852782 hasConcept C81885089 @default.
• W2024852782 hasConcept C86803240 @default.
• W2024852782 hasConcept C95444343 @default.
• W2024852782 hasConceptScore W2024852782C104317684 @default.
• W2024852782 hasConceptScore W2024852782C134305767 @default.
• W2024852782 hasConceptScore W2024852782C1491633281 @default.
• W2024852782 hasConceptScore W2024852782C153911025 @default.
• W2024852782 hasConceptScore W2024852782C16613235 @default.
• W2024852782 hasConceptScore W2024852782C171350616 @default.
• W2024852782 hasConceptScore W2024852782C177336024 @default.
• W2024852782 hasConceptScore W2024852782C22744801 @default.
• W2024852782 hasConceptScore W2024852782C25602115 @default.
• W2024852782 hasConceptScore W2024852782C522857546 @default.
• W2024852782 hasConceptScore W2024852782C54009773 @default.
• W2024852782 hasConceptScore W2024852782C54355233 @default.
• W2024852782 hasConceptScore W2024852782C552990157 @default.
• W2024852782 hasConceptScore W2024852782C55493867 @default.
• W2024852782 hasConceptScore W2024852782C62112901 @default.
• W2024852782 hasConceptScore W2024852782C81885089 @default.
• W2024852782 hasConceptScore W2024852782C86803240 @default.
• W2024852782 hasConceptScore W2024852782C95444343 @default.
• W2024852782 hasLocation W20248527821 @default.
• W2024852782 hasLocation W20248527822 @default.
• W2024852782 hasOpenAccess W2024852782 @default.
• W2024852782 hasPrimaryLocation W20248527821 @default.
• W2024852782 hasRelatedWork W1437140360 @default.
• W2024852782 hasRelatedWork W1905750137 @default.
• W2024852782 hasRelatedWork W1965194491 @default.
• W2024852782 hasRelatedWork W1975239850 @default.
• W2024852782 hasRelatedWork W1993469796 @default.
• W2024852782 hasRelatedWork W1998758780 @default.
• W2024852782 hasRelatedWork W2033334519 @default.
• W2024852782 hasRelatedWork W2054632884 @default.
• W2024852782 hasRelatedWork W2059758664 @default.
• W2024852782 hasRelatedWork W2086992094 @default.
• W2024852782 hasRelatedWork W2100550233 @default.
• W2024852782 hasRelatedWork W2105513775 @default.
• W2024852782 hasRelatedWork W2140944222 @default.
• W2024852782 hasRelatedWork W2146437352 @default.
• W2024852782 hasRelatedWork W2154468838 @default.

• next