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• W2024853323 abstract "Serotonin (5-HT) closes a specific K channel (“S”) in the cell body of Aplysia sensory neurons, resulting in a slow excitatory postsynaptic potential and spike broadening. To determine whether the S channel is present and can be modulated in processes of the neuron other than the cell body, we studied the effects of 5-HT on growth cones of sensory neurons in culture by using the patch-clamp technique. Simultaneous application of 5-HT to the cell body and to the growth cones of sensory neurons produced, in both, a slow depolarization of ∼5 mV. Also, 5-HT produced a lengthening of the duration of action potential in the growth cone and cell body by 20-30%. Similar effects were observed in isolated growth cones that had been severed from the rest of the neuron, implying that the growth cones contain all the molecular components (i.e., receptors, channels, cAMP cascade) necessary for 5-HT action. Cell-attached patch-clamp recordings demonstrated the presence of S channels in sensory neuron growth cones. Application of serotonin to the bath produced long-lasting all-or-none closures of these channels in a manner identical to the previously characterized action of 5-HT in the cell body. Thus, channel modulation is not restricted to the cell body and probably occurs throughout the sensory neuron. This strengthens the view that S-channel modulation may also occur at the sensory neuron presynaptic terminal, where it could play a role in the presynaptic facilitation produced by 5-HT." @default.
• W2024853323 created "2016-06-24" @default.
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• W2024853323 date "1986-09-01" @default.
• W2024853323 modified "2023-09-26" @default.
• W2024853323 title "The growth cones of <i>Aplysia</i> sensory neurons: Modulation by serotonin of action potential duration and single potassium channel currents" @default.
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• W2024853323 doi "https://doi.org/10.1073/pnas.83.18.7094" @default.
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