Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024853940> ?p ?o ?g. }
- W2024853940 endingPage "229" @default.
- W2024853940 startingPage "217" @default.
- W2024853940 abstract "In diploid populations of size N, there will be 2 Nμ mutations per nucleotide (nt) site (or per locus) per generation (μ stands for mutation rate). If either the population or the coding genome double in size, one expects 4 Nμ mutations. What is important is not the population size per se but the number of genes (coding sites), the two being often interconverted. Here we compared the total physical length of protein-coding genomes (n) with the corresponding absolute rates of synonymous substitution (KS), an empirical neutral reference. In the classical occupancy problem and in the coupons collector (CC) problem, n was expressed as the mean rate of change (KCC). Despite inherently very low power of the approaches involving averaging of rates, the mode of molecular evolution of the total size phenotype of the coding genome could be evidenced through differences between the genomic estimates of KCC [KCC=1/(ln n + 0.57721) n] and rate of molecular evolution, KS. We found that (1) the estimates of n and KS are reciprocally correlated across taxa (r=0.812; p≪ 0.001); (2) the gamete-cell division hypothesis (Chang et al. Proc Natl Acad Sci USA 91:827–831, 1994) can be confirmed independently in terms of KCC/KS ratios; (3) the time scale of molecular evolution changes with change in mutation rate, as previously shown by Takahata (Proc Natl Acad Sci USA 87:2419–2423, 1990), Takahata et al. (Genetics 130:925–938, 1992), and Vekemans and Slatkin (Genetics 137:1157–1165, 1994); (4) the generation time and population size (Lynch and Conery, Science 302:1401–1404, 2003) effects left their “signatures” at the level of the size phenotype of the protein-coding genome." @default.
- W2024853940 created "2016-06-24" @default.
- W2024853940 creator A5000116987 @default.
- W2024853940 creator A5047206085 @default.
- W2024853940 creator A5048745441 @default.
- W2024853940 creator A5058724451 @default.
- W2024853940 creator A5071214836 @default.
- W2024853940 creator A5080533920 @default.
- W2024853940 creator A5081440046 @default.
- W2024853940 date "2005-05-01" @default.
- W2024853940 modified "2023-10-16" @default.
- W2024853940 title "Size of the protein-coding genome and rate of molecular evolution" @default.
- W2024853940 cites W1502061430 @default.
- W2024853940 cites W1579785391 @default.
- W2024853940 cites W1617947194 @default.
- W2024853940 cites W1624098467 @default.
- W2024853940 cites W1907089350 @default.
- W2024853940 cites W1907806866 @default.
- W2024853940 cites W1956575226 @default.
- W2024853940 cites W1968179480 @default.
- W2024853940 cites W1968561408 @default.
- W2024853940 cites W1974365473 @default.
- W2024853940 cites W1977852064 @default.
- W2024853940 cites W1980897138 @default.
- W2024853940 cites W1984104678 @default.
- W2024853940 cites W1986820028 @default.
- W2024853940 cites W1988297489 @default.
- W2024853940 cites W1988714210 @default.
- W2024853940 cites W1992339555 @default.
- W2024853940 cites W1994066804 @default.
- W2024853940 cites W1996515220 @default.
- W2024853940 cites W1996733811 @default.
- W2024853940 cites W1997012028 @default.
- W2024853940 cites W1997188744 @default.
- W2024853940 cites W1999536502 @default.
- W2024853940 cites W1999836862 @default.
- W2024853940 cites W2005100412 @default.
- W2024853940 cites W2007325254 @default.
- W2024853940 cites W2010330824 @default.
- W2024853940 cites W2011331137 @default.
- W2024853940 cites W2014094060 @default.
- W2024853940 cites W2016869821 @default.
- W2024853940 cites W2018643684 @default.
- W2024853940 cites W2019934606 @default.
- W2024853940 cites W2021620549 @default.
- W2024853940 cites W2027574957 @default.
- W2024853940 cites W2027588766 @default.
- W2024853940 cites W2029158589 @default.
- W2024853940 cites W2032850607 @default.
- W2024853940 cites W2034801521 @default.
- W2024853940 cites W2041877136 @default.
- W2024853940 cites W2042903453 @default.
- W2024853940 cites W2044732887 @default.
- W2024853940 cites W2046515166 @default.
- W2024853940 cites W2046826691 @default.
- W2024853940 cites W2049089966 @default.
- W2024853940 cites W2050669549 @default.
- W2024853940 cites W2051814192 @default.
- W2024853940 cites W2053109557 @default.
- W2024853940 cites W2053501576 @default.
- W2024853940 cites W2054017637 @default.
- W2024853940 cites W2054293401 @default.
- W2024853940 cites W2057375490 @default.
- W2024853940 cites W2057979557 @default.
- W2024853940 cites W2060633986 @default.
- W2024853940 cites W2063209262 @default.
- W2024853940 cites W2063275805 @default.
- W2024853940 cites W2079027243 @default.
- W2024853940 cites W2089814091 @default.
- W2024853940 cites W2092231956 @default.
- W2024853940 cites W2098785512 @default.
- W2024853940 cites W2098902465 @default.
- W2024853940 cites W2100278941 @default.
- W2024853940 cites W2100856331 @default.
- W2024853940 cites W2101067655 @default.
- W2024853940 cites W2102131597 @default.
- W2024853940 cites W2102691281 @default.
- W2024853940 cites W2105299160 @default.
- W2024853940 cites W2107495006 @default.
- W2024853940 cites W2113141249 @default.
- W2024853940 cites W2127230663 @default.
- W2024853940 cites W2131494350 @default.
- W2024853940 cites W2142957146 @default.
- W2024853940 cites W2144386534 @default.
- W2024853940 cites W2146397496 @default.
- W2024853940 cites W2147932017 @default.
- W2024853940 cites W2149943693 @default.
- W2024853940 cites W2151464048 @default.
- W2024853940 cites W2153529713 @default.
- W2024853940 cites W2157843019 @default.
- W2024853940 cites W2160708989 @default.
- W2024853940 cites W2168909179 @default.
- W2024853940 cites W2173518071 @default.
- W2024853940 cites W2258331194 @default.
- W2024853940 cites W2284374475 @default.
- W2024853940 cites W2331240949 @default.
- W2024853940 cites W3012079654 @default.
- W2024853940 cites W4251921501 @default.